Allergic Aspergillus Rhinosinusitis

被引:34
作者
Chakrabarti, Arunaloke [1 ]
Kaur, Harsimran [1 ]
机构
[1] Postgrad Inst Med Educ & Res PGIMER, Dept Med Microbiol, Chandigarh 160012, India
关键词
fungal sinusitis; allergy; Aspergillus; dematiaceous fungi; epidemiology; pathogenesis; diagnosis; management;
D O I
10.3390/jof2040032
中图分类号
Q93 [微生物学];
学科分类号
071005 ; 100705 ;
摘要
Allergic fungal rhinosinusitis (AFRS) is a unique variety of chronic polypoid rhinosinusitis usually in atopic individuals, characterized by presence of eosinophilic mucin and fungal hyphae in paranasal sinuses without invasion into surrounding mucosa. It has emerged as an important disease involving a large population across the world with geographic variation in incidence and epidemiology. The disease is surrounded by controversies regarding its definition and etiopathogenesis. A working group on "Fungal Sinusitis" under the International Society for Human and Animal Mycology (ISHAM) addressed some of those issues, but many questions remain unanswered. The descriptions of "eosinophilic fungal rhinosinusitis" (EFRS), "eosinophilic mucin rhinosinusitis" (EMRS) and mucosal invasion by hyphae in few patients have increased the problem to delineate the disease. Various hypotheses exist for etiopathogenesis of AFRS with considerable overlap, though recent extensive studies have made certain in depth understanding. The diagnosis of AFRS is a multi-disciplinary approach including the imaging, histopathology, mycology and immunological investigations. Though there is no uniform management protocol for AFRS, surgical clearing of the sinuses with steroid therapy are commonly practiced. The role of antifungal agents, leukotriene antagonists and immunomodulators is still questionable. The present review covers the controversies, recent advances in pathogenesis, diagnosis, and management of AFRS.
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页数:29
相关论文
共 263 条
[1]   IL-17A Induces Pendrin Expression and Chloride-Bicarbonate Exchange in Human Bronchial Epithelial Cells [J].
Adams, Kelly M. ;
Abraham, Valsamma ;
Spielman, Daniel ;
Kolls, Jay K. ;
Rubenstein, Ronald C. ;
Conner, Gregory E. ;
Cohen, Noam A. ;
Kreindler, James L. .
PLOS ONE, 2014, 9 (08)
[2]  
Adelson Robert Todd, 2005, J Otolaryngol, V34 Suppl 1, pS18
[3]  
Aeumjaturapat Songklot, 2003, J Med Assoc Thai, V86, P420
[4]   Local production of antigen-specific IgE in different anatomic subsites of allergic fungal rhinosinusitis patients [J].
Ahn, Chadwick N. ;
Wise, Sarah K. ;
Lathers, Deanne M. R. ;
Mulligan, Ryan M. ;
Harvey, Richard J. ;
Schlosser, Rodney J. .
OTOLARYNGOLOGY-HEAD AND NECK SURGERY, 2009, 141 (01) :97-103
[5]  
Al-Radadi AM, 2011, J PAK MED ASSOC, V61, P704
[6]  
ALLPHIN AL, 1991, LARYNGOSCOPE, V101, P815, DOI 10.1288/00005537-199108000-00003
[7]   PURIFICATION AND CHARACTERIZATION OF FACTORS PRODUCED BY ASPERGILLUS-FUMIGATUS WHICH AFFECT HUMAN CILIATED RESPIRATORY EPITHELIUM [J].
AMITANI, R ;
TAYLOR, G ;
ELEZIS, EN ;
LLEWELLYNJONES, C ;
MITCHELL, J ;
KUZE, F ;
COLE, PJ ;
WILSON, R .
INFECTION AND IMMUNITY, 1995, 63 (09) :3266-3271
[8]   Imaging features of invasive and noninvasive fungal sinusitis: A review [J].
Aribandi, Manohar ;
McCoy, Victor A. ;
Bazan, Carlos, III .
RADIOGRAPHICS, 2007, 27 (05) :1283-1296
[9]   IL-22 mediates mucosal host defense against Gram-negative bacterial pneumonia [J].
Aujla, Shean J. ;
Chan, Yvonne R. ;
Zheng, Mingquan ;
Fei, Mingjian ;
Askew, David J. ;
Pociask, Derek A. ;
Reinhart, Todd A. ;
McAllister, Florencia ;
Edeal, Jennifer ;
Gaus, Kristi ;
Husain, Shahid ;
Kreindler, James L. ;
Dubin, Patricia J. ;
Pilewski, Joseph M. ;
Myerburg, Mike M. ;
Mason, Carol A. ;
Iwakura, Yoichiro ;
Kolls, Jay K. .
NATURE MEDICINE, 2008, 14 (03) :275-281
[10]   Increased presence of dendritic cells and dendritic cell chemokines in the sinus mucosa of chronic rhinosinusitis with nasal polyps and allergic fungal rhinosinusitis [J].
Ayers, Chris M. ;
Schlosser, Rodney J. ;
O'Connell, Brendan P. ;
Atkinson, Carl ;
Mulligan, Ryan M. ;
Casey, Sarah E. ;
Bleier, Benjamin S. ;
Wang, Eric W. ;
Sansoni, Eugene R. ;
Kuhlen, James L. ;
Mulligan, Jennifer K. .
INTERNATIONAL FORUM OF ALLERGY & RHINOLOGY, 2011, 1 (04) :296-302