CLINICAL OBSERVATIONS IN SHAMI GOAT KIDS SEDATED WITH MEDETOMIDINE

被引:20
作者
MOHAMMAD, FK
ZANGANA, IK
ALKASSIM, NA
机构
[1] Department of Physiology, Biochemistry and Pharmacology, College of Veterinary Medicine, University of Mosul, Mosul
[2] Department of Internal and Preventive Medicine, College of Veterinary Medicine, University of Mosul, Mosul
关键词
D O I
10.1016/0921-4488(91)90039-S
中图分类号
S8 [畜牧、 动物医学、狩猎、蚕、蜂];
学科分类号
0905 ;
摘要
The sedative action and side effects of medetomidine were recorded in five Shami goat kids. Intramuscular injection of medetomidine at 15-mu-g/kg caused recumbency in the kids in 11 +/- 4 min (mean +/- SD). The duration of recumbency and latency to onset of standing were 59 +/- 13 and 17 +/- 15 min, respectively. In the recumbent animals, the major side effects of medetomidine were bradycardia, hypothermia and stasis of the rumen. Other clinical side effects were salivation, bloating, frequent urination, jugular pulsation, mydriasis, polypnea and dyspnea. The side effects of medetomidine disappeared after standing for 1.5-2 h. The results suggested that medetomidine reliably induced sedation and recumbency in goat kids, and the animals recovered from the sedative effect of medetomidine without any apparent adverse effect.
引用
收藏
页码:149 / 153
页数:5
相关论文
共 22 条
  • [1] Booth, Non-narcotic analgesics, Veterinary Pharmacology and Therapeutics, pp. 297-320, (1982)
  • [2] Bruning, Kintz, Computational Handbook of Statistics, (1977)
  • [3] Greene, Thurmon, Xylazine — a review of its pharmacology and use in veterinary medicine, J. Vet. Pharmacol. Ther., 11, pp. 295-313, (1988)
  • [4] Hsu, Schaffer, Hanson, Effect of tolazoline and yohimbine on xylazine-induced central nervous system depression, bradycardia, and tachypnea in sheep, J. Am. Vet. Med. Assoc., 190, pp. 423-426, (1987)
  • [5] Jalanka, The use of medetomidine, medetomidine-ketamine combinations and atipamezole at Helsinki Zoo — a review of 240 cases, Domitor Symposium, 85, pp. 193-197, (1989)
  • [6] Kamerling, Gravens, Bagwell, Dose related effects of detomidine on autonomic response in the horse, Journal of Autonomic Pharmacology, 8, pp. 241-249, (1988)
  • [7] Kokkonen, Eriksson, Cardiovascular and allied actions of xylazine and atropine in the unanaesthetized goat, J. Vet. Pharmacol. Ther., 10, pp. 11-16, (1987)
  • [8] Kumar, Thurmon, Cardiopulmonary, hemocytologic and biochemical effects of xylazine in goats, Lab. Anim. Sci., 29, pp. 486-491, (1979)
  • [9] MacDonald, Scheinin, Scheinin, Behavioural and neurochemical effects of medetomidine, a novel veterinary sedative, Eur. J. Pharmacol., 158, pp. 119-127, (1988)
  • [10] MacDonald, Haapalinna, Virtanen, Lammintausta, Effects of acute administration of medetomidine on the behaviour, temperature and turnover rates of brain biogenic amines in rodents and reversal of these effects by atipamezole, Domitor Symposium, 85, pp. 77-81, (1989)