VALUES OF APO-AI AND APO-B IN HUMANS ACCORDING TO AGE AND SEX

Two series of 100 subjects each, males and females, were studied for the determination of plasma values of apo-AI, the major peptide of high density lipoprotein and of apo-B, the major peptide of low density lipoprotein. To minimize a possible influence of variations in plasma lipid levels, 2 series of subjects were selected with very similar mean values of plasma cholesterol and triglyceride. Despite this criterion of selection apo-A1 was significantly lower in males (127 .+-. 18 mg/l) than in females (137 .+-. 15 mg/l) while the reverse was true for apo-B (99 .+-. 16 mg/l in males vs. 91 .+-. 15 mg/l in females). Both apo-B and apo-A1 showed a tendency to increase with advancing age with the greatest increase for apo-AI (in both sexes) and for apo-B (only in males) from the 3rd to the 4th decade of age.