L-HISTIDINE INDUCED CHANGES IN ADENOSINE 3'-5'-MONOPHOSPHATE LEVELS IN RAT-BRAIN AND AMOUNTS OF APO-FATTY ACID, HOLO-A AND HOLO-B FATTY-ACID SYNTHETASES IN RAT-LIVER

When fasted rats were fed a chow or fat-free diet supplemented 5% with L-histidine for three days, the brain adenosine 3′:5′-monophosphate (cAMP) level increased. A 50% increase occurred in rats fed a chow diet and 20% increase in rats fed a fat-free diet. Purification of liver fatty acid synthetase and the isolation of liver apo-, holo-a and holo-b fatty acid synthetases demonstrated that L-histidine feeding caused changes in the relative amounts of these enzymes. Apo- and holo-b fatty acid synthetases increased while the holo-a form simultaneously decreased. This effect was observed in rats fed either chow or fat-free diets supplemented with L-histidine. © 1978.