AGONIST-SPECIFIC COUPLING OF A CLONED DROSOPHILA OCTOPAMINE TYRAMINE RECEPTOR TO MULTIPLE 2ND MESSENGER SYSTEMS

被引：213

作者：

ROBB, S

CHEEK, TR

HANNAN, FL

HALL, LM

MIDGLEY, JM

EVANS, PD

机构：

[1] UNIV CAMBRIDGE,DEPT ZOOL,AFRC,MOLEC SIGNALLING LAB,CAMBRIDGE CB2 3EJ,ENGLAND

[2] SUNY BUFFALO,SCH PHARM,DEPT BIOCHEM PHARMACOL,BUFFALO,NY 14260

[3] UNIV STRATHCLYDE,DEPT PHARMACEUT SCI,GLASGOW G1 1XW,SCOTLAND

来源：

EMBO JOURNAL | 1994年 / 13卷 / 06期

关键词：

DROSOPHILA; G-PROTEIN-COUPLED RECEPTORS; OCTOPAMINE; 2ND MESSENGERS; TYRAMINE;

D O I：

10.1002/j.1460-2075.1994.tb06385.x

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A cloned seven transmembrane-spanning Drosophila octopamine/tyramine receptor, permanently expressed in a Chinese hamster ovary cell line, both inhibits adenylate cyclase activity and leads to the elevation of intracellular Ca2+ levels by separate G-protein-coupled pathways. Agonists of this receptor (octopamine and tyramine), differing by only a single hydroxyl group in their side chain, may be capable of differentially coupling it to different second messenger systems. Thus, a single receptor may have a different pharmacological profile depending on which second messenger system is used to assay its efficacy.

引用

页码：1325 / 1330

页数：6

共 41 条

[1] EXPRESSION CLONING OF A COMMON RECEPTOR FOR PARATHYROID-HORMONE AND PARATHYROID HORMONE-RELATED PEPTIDE FROM RAT OSTEOBLAST-LIKE CELLS - A SINGLE RECEPTOR STIMULATES INTRACELLULAR ACCUMULATION OF BOTH CAMP AND INOSITOL TRISPHOSPHATES AND INCREASES INTRACELLULAR FREE CALCIUM [J].