Nanoparticle-Lipid Interaction: Job Scattering Plots to Differentiate Vesicle Aggregation from Supported Lipid Bilayer Formation

被引：7

作者：

Mousseau, Fanny ^{[1
]}

Oikonomou, Evdokia K. ^{[1
]}

Baldim, Victor ^{[1
]}

Mornet, Stephane ^{[2
]}

Berret, Jean-Francois ^{[1
]}

机构：

[1] Univ Denis Diderot Paris VII, Mat & Syst Complexes, UMR 7057 CNRS, Batiment Condorcet, F-75205 Paris, France

[2] Univ Bordeaux 1, UPR CNRS 9048, Inst Chim Mat Condensee Bordeaux, 87 Ave Docteur A Schweitzer, F-33608 Pessac, France

来源：

COLLOIDS AND INTERFACES | 2018年 / 2卷 / 04期

关键词：

nanoparticles; bio-nano interfaces; electrostatic interactions; supported lipid bilayers;

D O I：

10.3390/colloids2040050

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

The impact of nanomaterials on lung fluids, or on the plasma membrane of living cells, has prompted researchers to examine the interactions between nanoparticles and lipid vesicles. Recent studies have shown that nanoparticle-lipid interaction leads to a broad range of structures including supported lipid bilayers (SLB), particles adsorbed at the surface or internalized inside vesicles, and mixed aggregates. Currently, there is a need to have simple protocols that can readily evaluate the structures made from particles and vesicles. Here we apply the method of continuous variation for measuring Job scattering plots and provide analytical expressions for the scattering intensity in various scenarios. The result that emerges from the comparison between experiments and modeling is that electrostatics play a key role in the association, but it is not sufficient to induce the formation of supported lipid bilayers.

引用

页数：11