AZT-INDUCED MITOCHONDRIAL MYOPATHY

被引：29

作者：

TOMELLERI, G

TONIN, P

SPADARO, M

TILIA, G

ORRICO, D

BARELLI, A

BONETTI, B

MONACO, S

SALVIATI, A

MOROCUTTI, C

RIZZUTO, N

机构：

[1] UNIV ROME LA SAPIENZA,IST CLIN MALATTIE NERVOSE & MENTALI,I-00185 ROME,ITALY

[2] OSPED CIVILE MESTRE,DIV MALATTIE INFETTIVE,MESTRE,ITALY

来源：

ITALIAN JOURNAL OF NEUROLOGICAL SCIENCES | 1992年 / 13卷 / 09期

关键词：

AIDS; AZT; MITOCHONDRIAL MYOPATHY; CYTOCHROME-C OXIDASE; SUCCINATE CYTOCHROME-C REDUCTASE; TYPE-2 FIBER ATROPHY;

D O I：

10.1007/BF02229156

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Histochemical, electron microscopy and biochemical studies were performed on muscle biopsy specimens from 11 AIDS patients treated with zidovudine. A peculiar association of structural abnormalities and mitochondrial dysfunction was found. Focal cytochrome c oxidase (COX) deficiency was evident in muscle sections from 9 patients, 8 of whom had received long-term treatment while one had been treated for 1 month only. Electron microscopy showed changes in number, size and structure of mitochondria. Biochemical studies proved partial COX and succinate cytochrome c reductase (SCR) deficiency in 4 patients; one patient had only reduced SCR activity. Our data confirm that AZT therapy can cause toxic myopathy with mitochondrial dysfunction.

引用

页码：723 / 728

页数：6

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