PHARMACOLOGICAL EFFECTS OF ADENOSINE ON CANINE PENILE ERECTION

被引：17

作者：

TAKAHASHI, Y ^{[1
]}

ISHII, N ^{[1
]}

LUE, TF ^{[1
]}

TANAGHO, EA ^{[1
]}

机构：

[1] UNIV CALIF SAN FRANCISCO, SCH MED, DEPT UROL, SAN FRANCISCO, CA 94143 USA

来源：

TOHOKU JOURNAL OF EXPERIMENTAL MEDICINE | 1991年 / 165卷 / 01期

关键词：

ADENOSINE; DIPYRIDAMOLE; THEOPHYLLINE; PENILE ERECTION; DOG;

D O I：

10.1620/tjem.165.49

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

We investigated the pharmacological effects of adenosine on canine penile erection in vivo. Intracavernous injection of adenosine induced a full erection, which was unaffected by hexamethonium and atropine. The erectile response induced by adenosine was augmented by intracavernous pretreatment with dipyridamole and markedly depressed by theophylline. The erectile response induced by cavernous nerve stimulation was also enhanced by dipyridamole and reduced by theophylline. The combination of acetylcholine and adenosine, when injected intracavernously, induced a full erection, and the effect of these drugs was not additive but synergistic. These results suggest that penile erection induced by adenosine is due to a direct relaxing effect on cavernous smooth muscle. We propose that adenosine plays a cooperative role with acetylcholine and also has a physiological role as a neuromodulator in canine penile erection.

引用

页码：49 / 58

页数：10

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