ANTIBACTERIAL ACTIVITY OF SELECTED PLANTS SPECIES EXTRACT CITED IN THE HOLY QURAN AGAINST CLINICAL ISOLATES

Background Medicinal plants have been regarded as new resources for generating substitutes to antibiotics against the antibiotic-resistant bacteria. Holy Quran is the reference which has described the significance of using plants for curing different diseases in various verses. The goal of this investigation was to evaluate 15 plant extracts cited in Holy Quran against the antibacterial activity and the other bacterial species isolated from humans. Methods: The activities of 15 plants' extract as well as some antibiotics against Escherichia coli, Staphylococcus aureus (MRSA), Klebsiella pneumonia, and Shigella sonnei were assessed through in vitro experiments. The activity against 4 isolates of each bacterium was identified by well diffusion method. For identifying the minimal inhibitory concentrations (MICs) of the plant extracts, Microdilution susceptibility assay was applied. Results: Among the evaluated plants, methanolic extract showed anti-bacterial activity and water extract indicated no activity. The minimum inhibitory concentration (MIC) values of these crude methanolic extracts against tested bacterial strains were indicated to range between 0.05 to 12.5 mu l/ml. It was found that all the examined extracts prevented the activity against the bacterial strains (p < 0.05). Conclusion: 15 plant extracts cited in Quran were found that could act as the bactericidal agents against Gram-negative and Gram-positive bacteria, and the potential candidate species to develop the novel veterinary drugs with low cost and few side effects. More research studies are required to investigate the novel antibacterial bioactive molecules. Copyright (c) 2013 - All Rights Reserved - Pharmacophore