CHRONIC XEROSTOMIA INCREASES ESOPHAGEAL ACID EXPOSURE AND IS ASSOCIATED WITH ESOPHAGEAL INJURY

被引：81

作者：

KORSTEN, MA ^{[1
]}

ROSMAN, AS ^{[1
]}

FISHBEIN, S ^{[1
]}

SHLEIN, RD ^{[1
]}

GOLDBERG, HE ^{[1
]}

BIENER, A ^{[1
]}

机构：

[1] CUNY MT SINAI SCH MED,NEW YORK,NY 10029

来源：

AMERICAN JOURNAL OF MEDICINE | 1991年 / 90卷 / 06期

关键词：

D O I：

10.1016/S0002-9343(05)80058-0

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

OBJECTIVE: To assess the effects of chronic xerostomia on parameters of gastroesophageal reflux and esophagitis. DESIGN: Observational study of a cohort of male patients with xerostomia and age-matched control subjects. SETTING: Tertiary-care Veterans Affairs Medical Center. SUBJECTS: Sixteen male patients with chronic xerostomia secondary to radiation for head and neck cancers or medications. Nineteen age-matched male control subjects with comparable alcohol and smoking histories. MEASUREMENTS AND MAIN RESULTS: Esophageal motility was similar in patients with xerostomia and controls. Clearance of acid from the esophagus and 24-hour intraesophageal pH were markedly abnormal in patients with xerostomia. Symptoms and signs of esophagitis were significantly more frequent in subjects with xerostomia. CONCLUSIONS: Chronic xerostomia may predispose to esophageal injury, at least in part, by decreasing the clearance of acid from the esophagus and altering 24-hour intraesophageal pH. Esophageal injury is a previously unreported complication of long-term salivary deficiency.

引用

页码：701 / 706

页数：6

共 21 条

[1] LOWER ESOPHAGEAL SPHINCTER PRESSURE AS AN INDEX OF GASTRO-ESOPHAGEAL ACID REFLUX [J].