STIMULATION OF MYENTERIC PLEXUS NEURITE OUTGROWTH BY INSULIN AND INSULIN-LIKE GROWTH FACTOR-I AND FACTOR-II

被引：15
|
作者：
MULHOLLAND, MW
ROMANCHUK, G
SIMEONE, DM
FLOWE, K
机构：
[1] Michigan Gastrointestinal Peptide Center, 2922 D Taubman, University of Michigan, Ann Arbor
来源：
LIFE SCIENCES | 1992年 / 51卷 / 23期
关键词：
D O I：
10.1016/0024-3205(92)90049-U
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
A defined culture medium containing insulin, insulin-like growth factor I (IGF-I) or insulin-like growth factor II (IGF-11) supported morphological development of myenteric plexus neurons derived from neonatal guinea pigs. Insulin increased neurite outgrowth 3-fold at concentrations as low as 0.2 nM. Similar significant and dose-dependent increases in neurite outgrowth were noted with IGF-I and IGF-II. Stimulation of neurite outgrowth was abolished by exposure to cytosine arabinofuranoside, an agent toxic to non-neuronal cells, implying that trophic effects of insulin or insulin-like growth factors require the presence of non-neuronal elements in culture.
引用
收藏
页码：1789 / 1796
页数：8
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