SYNTHESIS OF SOME NEW 7-SUBSTITUTED AMINOMETHYL-6-CHLOROQUINOLINE-5,8-QUINONES

Some new 7-alkyl (or aryl) aminomethyl-6-chloroquinoline-5,8-quinones (II) have been obtained through the reaction of 6-chloroquinoline-5,8-quinone with primary aliphatic or aromatic amines and paraformaldehyde in ethanol. On using secondary amines such as piperidine or morpholine in the above reaction, 6-chloro-7-piperidino (or morpholino) methylquinoline-5,8-quinone (III) and (IV) respectively were obtained. The structure of the synthesised compounds was confirmed by elemental analysis and spectral data. The synthesised compounds were also biologically evaluated.