SYNTHESIS OF GAMMA-HYDROXY KETONES BY LICLO4-CATALYZED ADDITION OF LITHIUM ENOLATES TO 1,2-EPOXIDES

被引：25

作者：

CHINI, M ^{[1
]}

CROTTI, P ^{[1
]}

FAVERO, L ^{[1
]}

PINESCHI, M ^{[1
]}

机构：

[1] UNIV PISA,DIPARTIMENTO CHIM BIOORGAN,VIA BONANNO 33,I-56126 PISA,ITALY

来源：

TETRAHEDRON LETTERS | 1991年 / 32卷 / 51期

关键词：

GAMMA-HYDROXY KETONES; EPOXIDE OPENING REACTIONS; REGIOSELECTIVITY; CATALYSTS;

D O I：

10.1016/0040-4039(91)80540-M

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A simple, efficient, anti-stereoselective, highly regioselective method is described for the synthesis of gamma-hydroxy ketones by the direct opening of 1,2-epoxides with lithium enolates derived from simple ketones in anhydrous THF, in the presence of LiClO4.

引用

页码：7583 / 7586

页数：4

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