REASSOCIATION WITH BETA-2-MICROGLOBULIN IS NECESSARY FOR KB CLASS-I MAJOR HISTOCOMPATIBILITY COMPLEX BINDING OF EXOGENOUS PEPTIDES

被引：119

作者：

ROCK, KL ^{[1
]}

ROTHSTEIN, LE ^{[1
]}

GAMBLE, SR ^{[1
]}

BENACERRAF, B ^{[1
]}

机构：

[1] HARVARD UNIV,SCH MED,DEPT PATHOL,BOSTON,MA 02115

来源：

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 1990年 / 87卷 / 19期

关键词：

antigen presentation; cytotoxic T lymphocyte; T lymphocyte;

D O I：

10.1073/pnas.87.19.7517

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

T lymphocytes recognize endogenously produced antigenic peptides in association with major histocompatibility complex (MHC)-encoded molecules. Peptides from the extracellular fluid can be displayed in association with class I and class II MHC molecules. Here we report that mature Kb class I MHC molecules bind peptides upon dissociation and reassociation of their light chain. Intact Kb heterodimers, unlike class II MHC molecules, are relatively unreceptive to binding peptides. This property may maintain segregation of class I and class II MHC-restricted peptides and has implications for the use of peptides as vaccines.

引用

页码：7517 / 7521

页数：5

共 25 条

[1] BETA-2-MICROGLOBULIN IS NOT REQUIRED FOR CELL-SURFACE EXPRESSION OF THE MURINE CLASS-I HISTOCOMPATIBILITY ANTIGEN H-2DB OR OF A TRUNCATED H-2DB [J].