Synthesis and biological studies of novel 2-(4-substitutedbenzylthio)-5-amino-6-(benzo[d] thiazol-2-yl)-7-(4-chlorophenyl)pyrido-[2,3-d]-pyrimidin-4(3H)-one derivatives

被引：0

作者：

Suresh, M. ^{[1
]}

Lavanya, P. ^{[2
]}

Raju, K. Naga ^{[2
]}

Jonnalagadda, Sreekanth B. ^{[1
]}

Rao, C. Venkata ^{[2
]}

机构：

[1] Univ KwaZulu Natal, Sch Chem, ZA-4000 Durban, South Africa

[2] Sri Venkateswara Univ, Coll Sci, Dept Chem, Tirupati 517502, Andhra Prades, India

来源：

ORGANIC COMMUNICATIONS | 2011年 / 4卷 / 02期

关键词：

2-(4-substitutedbenzylthio)-5-amino-6-(benzo[d] thiazol-2-yl)-7-(4-chlorophenyl)pyrido[2,3-d]-pyrimidin-4(3H)-one; antibacterial; antifungal;

D O I：

暂无

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A series of novel 2-(4-substitutedbenzylthio)-5-amino-6-(benzo[d]thiazol-2-yl)-7-(4-chlorophenyl) pyrido[2,3-d]pyrimidin-4(3H)-one derivatives were synthesized and evaluated for their antibacterial and antifungal activity. All the derivatives were efficiently synthesized in four steps. The structure of the newly synthesized compounds was elucidated by their IR, H-1-NMR, C-13 NMR, LCMS mass spectra and elemental analysis.

引用

页码：33 / 41

页数：9

共 50 条

[21] Synthesis of 2-substituted pyrano[2,3-d]pyrimidin-4(3H)-one derivatives using iminophosphorane
Re, Qing-Yun
He, Hong-Wu
PHOSPHORUS SULFUR AND SILICON AND THE RELATED ELEMENTS, 2008, 183 (2-3) : 629 - 630
[22] Synthesis and Antitumor Activity of Some Novel 5,6,7,8-Tetrahydrobenzo-thieno[2,3-d]pyrimidin-4(3H)-one Derivatives
Wang, Hongmei
Guo, Shubing
Hu, Yanggen
Zeng, Xiaohua
Yang, Guangyi
CHINESE JOURNAL OF ORGANIC CHEMISTRY, 2015, 35 (05) : 1075 - 1080
[23] A Convenient Synthesis and Biological Activity of Novel Pyrido[4,3-d]pyrimidin-4(3H)-ones
Ren, Qingyun
Xia, ShiYan
Gu, Yucheng
Li, Baoju
He, Hongwu
JOURNAL OF HETEROCYCLIC CHEMISTRY, 2015, 52 (03) : 647 - 652
[24] A Convenient Synthesis and Biological Activity of Novel Pyrido[4,3-d] pyrimidin-4(3H)-ones
Ren, Qingyun
Shi, YanXia
Gu, Yucheng
Li, Baoju
He, Hongwu
JOURNAL OF HETEROCYCLIC CHEMISTRY, 2014, 51 (02) : 285 - 290
[25] Synthesis, crystal structure and fungicidal activity of tetrahydrobenzo[4′,5′]thieno[3′,2′:5,6]pyrido[4,3-d]pyrimidin-4(3H)-one derivatives
Ren, Qing-Yun
He, Hong-Wu
Liu, Jian-Chao
CHINESE JOURNAL OF ORGANIC CHEMISTRY, 2007, 27 (03) : 397 - 401
[26] Development of 2-aryl substituted quinazolin-4(3H)-one, pyrido [4,3-d]pyrimidin-4(3H)-one and pyrido [4,3-d]pyrimidin-4(3H)-one derivatives as microsomal prostaglandin E2 synthase-1 inhibitors
Banerjee, Abhisek
Pawar, Mahesh Y.
Patil, Sandip
Yadav, Pravin S.
Kadam, Pradip A.
Kattige, Vidya G.
Deshpande, Durga S.
Pednekar, Pallavi V.
Pisat, Monali K.
Gharat, Laxmikant A.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2014, 24 (20) : 4838 - 4844
[27] Efficient synthesis of furo[2,3-d]pyrimidin-4(3H)-ones
Hu, Yang-Gen
Li, Gui-Hua
Ding, Ming-Wu
ARKIVOC, 2008, : 151 - 158
[28] Synthesis and Biological Evaluation of 5,6-Dimethylthieno[2,3-d]Pyrimidin-4(3H)-One Derivatives as Selective Cyclooxygenase 2 Inhibitors
Mun, Lim Tse
Kean, Jamie Kow
Deb, Pran Kishore
Venugopala, Katharigatta Narayanaswamy
Mailavaram, Raghu Prasad
Binsaleh, Ammena Yahia
Shilbayeh, Sireen Abdul Rahim
INDIAN JOURNAL OF PHARMACEUTICAL EDUCATION AND RESEARCH, 2024, 58 (02) : s515 - s520
[29] 2-(4-Chlorophenoxy)-3-isopropyl-5,6,7,8-tetrahydro-2-benzothieno[2,3-d] pyrimidin-4(3H)-one
Zeng, XH
Ding, MW
He, HW
ACTA CRYSTALLOGRAPHICA SECTION E-STRUCTURE REPORTS ONLINE, 2006, 62 : O731 - O732
[30] Synthesis and Antibacterial and Antifungal Activity of New Thieno[2,3-d]Pyrimidin-4(3H)-One Derivatives
B. Kahveci
İ. S. Doğan
E. Menteşe
H. E. Sellitepe
D. Kart
Pharmaceutical Chemistry Journal, 2020, 54 : 647 - 653

← 1 2 3 4 5 →