STUDIES WITH LB 46, A NEW BETA-RECEPTOR BLOCKING DRUG

被引：49

作者：

LUBAWSKI, I

WALE, J

机构：

[1] Department of Pharmacology, University of Melbourne, Parkville

来源：

EUROPEAN JOURNAL OF PHARMACOLOGY | 1969年 / 6卷 / 03期

关键词：

Specificity of action - LB 46; Specificity of action - propranolol; β-receptor antagonists;

D O I：

10.1016/0014-2999(69)90195-2

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The specificity of the β-receptor antagonists propranolol and LB 46 [4-(2-hydroxy-3-isopropyl-aminopropoxy)-indole] has been compared by determination of their quinidine-like activities and antagonistic activity against isoprenaline, adrenaline, acetylcholine and histamine. LB 46 was 5 to 10 times more potent than propranolol as a β-receptor antagonist. It had stronger antimuscarinic activity, weaker antihistaminic activity and a slightly weaker quinidine-like activity than propranolol. © 1969.

引用

页码：345 / &