ANTINOCICEPTIVE ACTIVITY OF CLONIDINE AND ITS POTENTIATION OF MORPHINE ANALGESIA

被引：206

作者：

SPAULDING, TC

FIELDING, S

VENAFRO, JJ

LAL, H

机构：

[1] Department of Pharmacology, Hoechst-Roussel Phamaceuticals, Inc., Somerville

[2] Department of Pharmacology, University of Rhoe Island, Kingston

来源：

EUROPEAN JOURNAL OF PHARMACOLOGY | 1979年 / 58卷 / 01期

关键词：

Antinociception; Clonidine; Cross tolerance; Morphine potentiation; Tail flick;

D O I：

10.1016/0014-2999(79)90335-2

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The activity of clonidine and its interaction with morphine was assesed in the mouse tail flick assay. In this assay, clonidine was found to be 10 times more potent than morphine. Clonidine potentiated morphine antinociceptive activity approximately five-fold and morphine potentiated clonidine activity four-fold. Clonidine's agonistic activity was not reversed by naloxone hydrochloride 910 mg/kg) while the potentiating effect of clonindine by morphine was. Tolerance to the antinociceptive effect of morphine was observed in morphine pellet-implanted mice byt no cross tolerance was observed for clonidine. These data indicate that clonidine-induced analgesia is not a result of an interaction at morphine receptors; but rather, common pathway(s) are present which appear to complement the agonistic interaction of each. © 1979.

引用

页码：19 / 25

页数：7

共 24 条

[1] DIFFERENT ALPHA-ADRENORECEPTORS IN CENTRAL NERVOUS-SYSTEM MEDIATING BIOCHEMICAL AND FUNCTIONAL EFFECTS OF CLONIDINE AND RECEPTOR BLOCKING-AGENTS [J].