SYNTHESIS AND BIOLOGICAL-ACTIVITY OF NEW OPTICALLY-ACTIVE 2-OXAISOCEPHEMS - 3-(N-ALKYLPYRIDINIUM-4'-THIO)METHYL DERIVATIVES

被引：9
|
作者：
ISHIKAWA, H
TSUBOUCHI, H
YASUMURA, K
机构：
[1] OTSUKA PHARMACEUT CO LTD,MICROBIOL RES INST,KAWAUCHI 77101,TOKUSHIMA,JAPAN
[2] OTSUKA PHARMACEUT CO LTD,FUJII MEM RES INST,OTSU 52001,SHIGA,JAPAN
来源：
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1994年 / 4卷 / 09期
关键词：
D O I：
10.1016/S0960-894X(01)80245-6
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
A convenient synthesis of new optically active 2-oxaisocephems with (N-alkylpyridinium-4'-thio)methyl groups at the 3-position and their biological activities are described. In particular, 10b and 10d having [2-(2-aminothiazol-4-yl)-2-(Z)-cyclopentyloxyimino]acetamido group at the 7-position were found to possess high in vitro potency and showed excellent in vivo efficacy.
引用
收藏
页码：1147 / 1152
页数：6
相关论文
共 50 条
  • [41] SYNTHESIS AND BIOLOGICAL-ACTIVITY OF 6-NITRO-2,2,4-TRIMETHYL-4-PHENYL-1,2,3,4-TETRAHYDROQUINOLINE N-BENZOYL DERIVATIVES
    SHMYREVA, ZV
    SHIKHALIEV, KS
    SHPANIG, EB
    IZVESTIYA VYSSHIKH UCHEBNYKH ZAVEDENII KHIMIYA I KHIMICHESKAYA TEKHNOLOGIYA, 1988, 31 (09): : 45 - 48
  • [42] SYNTHESIS AND BIOLOGICAL-ACTIVITY OF 4,5-DIPHENYL-1,2,4-TRIAZOLYL-3-PROPIONIC ACID AND ITS DERIVATIVES
    VASSILEV, GN
    DEMIROV, G
    DOKLADI NA BOLGARSKATA AKADEMIYA NA NAUKITE, 1980, 33 (02): : 265 - 268
  • [43] SYNTHESIS, STRUCTURE AND BIOLOGICAL-ACTIVITY OF SOME DERIVATIVES OF 4-URACYL-5-PHENYL-3(2H)-PYRIDAZINONE
    GEORGIEV, GM
    VASSILEV, GN
    DRYANOVSKANONINSKA, LA
    GEORGIEVA, MI
    CHIZHOV, OS
    ZOLOTAREV, BM
    DOKLADI NA BOLGARSKATA AKADEMIYA NA NAUKITE, 1980, 33 (10): : 1385 - 1388
  • [44] THE SYNTHESIS AND BIOLOGICAL-ACTIVITY OF METHYL 5-[(AMINO) (PARA-FLUOROPHENYL)METHYL]BENZIMIDAZOL-2-YL CARBAMATE AND RELATED DERIVATIVES - ORALLY ACTIVE MACROFILARICIDAL AGENTS
    WISE, DS
    RAM, S
    DZIMIANSKI, MT
    MCCALL, JW
    TOWNSEND, LB
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 1992, 204 : 147 - MEDI
  • [45] SYNTHESIS AND BIOLOGICAL-ACTIVITY OF SOME NEW N-CYCLOHEXYL-N'-ALKYL-N'-(3-CYCLOALCOXY-2-HYDROXYPROPYL)-UREAS
    VASSILEV, GN
    GAGAOUZOV, YN
    CHALINA, EG
    DIMCHEVA, ZP
    DOKLADI NA BOLGARSKATA AKADEMIYA NA NAUKITE, 1989, 42 (07): : 89 - 92
  • [46] SYNTHESIS OF NEW ORGANIC-PHOSPHATES WITH POTENTIAL INSECTICIDAL PROPERTIES .1. SYNTHESIS AND BIOLOGICAL-ACTIVITY OF 2-SR-1,3,2-BENZOXATHIAPHOSPHOLE-2-THIO
    RUVEDA, MA
    ZERBA, EN
    DELICASTRO, SA
    DEMALDAO, E
    WOOD, JE
    PICOLLO, MI
    ANALES DE LA ASOCIACION QUIMICA ARGENTINA, 1975, 63 (5-6): : 265 - 269
  • [47] SYNTHESIS AND BIOLOGICAL-ACTIVITY OF SOME NEW N-3(2PHENYL QUINAZOLIN(3H)-4-ONE) ACYL HYDRAZONES
    SENGUPTA, AK
    CHANDRA, U
    JOURNAL OF THE INDIAN CHEMICAL SOCIETY, 1979, 56 (06) : 645 - 647
  • [48] SYNTHESIS OF OPTICALLY-ACTIVE (PIVALOYLOXY)METHYL 2',3'-SUBSTITUTED 4'-OXOAZETIDIN-1'-YL-3-METHYLBUT-2-ENOATES FROM 6-APA
    SOMOZA, C
    MASCARETTI, OA
    TETRAHEDRON, 1988, 44 (23) : 7007 - 7012
  • [49] SYNTHESIS AND BIOLOGICAL-ACTIVITY OF THE FUNCTIONAL-DERIVATIVES OF 3-(DIMETHYLAMINOMETHYL)-1,2-DITHIOLANES AND 4-(DIMETHYLAMINOMETHYL)-1,2-DITHIOLANES
    UNEME, H
    MITSUDERA, H
    YAMADA, J
    KAMIKADO, T
    KONO, Y
    MANABE, Y
    NUMATA, M
    BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY, 1992, 56 (10) : 1623 - 1631
  • [50] SYNTHESIS AND BIOLOGICAL-ACTIVITY OF SOME NEW 2-(N-SUBSTITUTED CARBOXAMIDOMETHYL THIO)NAPHTH[1,2-D]OXAZOLES .5.
    MAHMOUD, AM
    ABDELRAHMAN, AE
    ELSHERIEF, HA
    JOURNAL OF THE INDIAN CHEMICAL SOCIETY, 1982, 59 (05) : 675 - 677
12345