SYNTHESIS AND BIOLOGICAL-ACTIVITY OF NEW OPTICALLY-ACTIVE 2-OXAISOCEPHEMS - 3-(N-ALKYLPYRIDINIUM-4'-THIO)METHYL DERIVATIVES

被引：9

作者：

ISHIKAWA, H

TSUBOUCHI, H

YASUMURA, K

机构：

[1] OTSUKA PHARMACEUT CO LTD,MICROBIOL RES INST,KAWAUCHI 77101,TOKUSHIMA,JAPAN

[2] OTSUKA PHARMACEUT CO LTD,FUJII MEM RES INST,OTSU 52001,SHIGA,JAPAN

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1994年 / 4卷 / 09期

关键词：

D O I：

10.1016/S0960-894X(01)80245-6

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A convenient synthesis of new optically active 2-oxaisocephems with (N-alkylpyridinium-4'-thio)methyl groups at the 3-position and their biological activities are described. In particular, 10b and 10d having [2-(2-aminothiazol-4-yl)-2-(Z)-cyclopentyloxyimino]acetamido group at the 7-position were found to possess high in vitro potency and showed excellent in vivo efficacy.

引用

页码：1147 / 1152

页数：6

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