BACTERIAL VIRULENCE CHARACTERISTICS OF ESCHERICHIA-COLI ISOLATES FROM FIRST-TIME URINARY-TRACT INFECTION

被引：101

作者：

FOXMAN, B ^{[1
]}

ZHANG, LX ^{[1
]}

PALIN, K ^{[1
]}

TALLMAN, P ^{[1
]}

MARRS, CF ^{[1
]}

机构：

[1] UNIV NEW ENGLAND, SCH OSTEOPATH MED, DEPT FAMILY MED, BIDDEFORD, ME USA

来源：

JOURNAL OF INFECTIOUS DISEASES | 1995年 / 171卷 / 06期

关键词：

D O I：

10.1093/infdis/171.6.1514

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The frequency of nine potential Escherichia coli urinary tract infection (UTI) virulence factors was investigated among 216 isolates from 208 women 18-40 years old with first-time UTI. Factors were afimbrial adhesins I-IV and F1845 pill (drb), aerobactin (aer), group II capsules (kpsMT), cytotoxic necrotizing factor 1 (cnf1), alpha-hemolysin (hly), outer membrane protease T (ompT), Pap and Prs pili (prf), S fimbriae (sfa), and type 1 pili (fim). Women were enrolled at two sites. Pairwise comparisons found 14 statistically significant associations between virulence genes after correcting for multiple comparisons. This is the first report of five associations: aer and drb, kpsMT and ompT, ompT and cnf1, ompT and sfa, and prf and ompT. As ompT is not closely linked genetically to kpsMT, cnf1, prf; or sfa, ompT may be functionally linked with one or more of these other virulence factors.

引用

页码：1514 / 1521

页数：8

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