ACTIVITY OF CATIONICALLY SUBSTITUTED BIS-BENZIMIDAZOLES AGAINST EXPERIMENTAL PNEUMOCYSTIS-CARINII PNEUMONIA

被引：101

作者：

TIDWELL, RR ^{[1
]}

JONES, SK ^{[1
]}

NAIMAN, NA ^{[1
]}

BERGER, LC ^{[1
]}

BRAKE, WB ^{[1
]}

DYKSTRA, CC ^{[1
]}

HALL, JE ^{[1
]}

机构：

[1] UNIV N CAROLINA, SCH PUBL HLTH, DEPT EPIDEMIOL, CHAPEL HILL, NC 27599 USA

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 1993年 / 37卷 / 08期

关键词：

D O I：

10.1128/AAC.37.8.1713

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

On the basis of a previously observed correlation between the antimicrobial activity and DNA binding strength of dicationic molecules, a series of 10 dicationically substituted bis-benzimidazoles were tested for activity in the rat model of Pneumocystis carinii pneumonia. One of the compounds, 1,4-bis[5-(2-imidazolinyl)-2-benzimidazolyl]butane, was found to be more potent and less toxic than pentamidine.

引用

页码：1713 / 1716

页数：4

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