BINDING OF 2-[I-125]MELATONIN BY RAT THYMUS MEMBRANES DURING POSTNATAL-DEVELOPMENT

被引：49
|
作者：
MARTINCACAO, A
LOPEZGONZALEZ, MA
REITER, RJ
CALVO, JR
GUERRERO, JM
机构：
[1] UNIV SEVILLE,SCH MED,DEPT MED BIOCHEM & MOLEC BIOL,AVDA SANCHEZ PIZJUAN 4,E-41009 SEVILLE,SPAIN
[2] UNIV TEXAS,HLTH SCI CTR,DEPT CELLULAR & STRUCT BIOL,SAN ANTONIO,TX 78284
来源：
IMMUNOLOGY LETTERS | 1993年 / 36卷 / 01期
关键词：
MELATONIN; PINEAL; THYMUS; IMMUNE SYSTEM;
D O I：
10.1016/0165-2478(93)90069-E
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Previously, we have demonstrated the presence of melatonin binding sites in thymus membranes of adult rats. In this paper, we show that the binding of melatonin by thymus membranes changes during postnatal development. Maximum binding was observed in newborn rats; thereafter, binding decreased progressively during the first weeks of life and exhibited the lowest values in adult animals. Stoichiometric studies showed that the decrease in melatonin binding was due to changes in the binding capacity (2.5-fold) rather than to changes in the affinity of the receptor for the ligand. The results suggest a physiological role of melatonin in regulating thymus activity early during postnatal development.
引用
收藏
页码：59 / 64
页数：6
相关论文
共 50 条
  • [1] SPECIFIC BINDING OF 2-[I-125]MELATONIN BY PARTIALLY PURIFIED MEMBRANES OF RAT THYMUS
    LOPEZGONZALEZ, MA
    MARTINCACAO, A
    CALVO, JR
    REITER, RJ
    OSUNA, C
    GUERRERO, JM
    JOURNAL OF NEUROIMMUNOLOGY, 1993, 45 (1-2) : 121 - 126
  • [2] Diurnal variations in [I-125]melatonin binding by rat thymus membranes: Effects of continuous light exposure and pinealectomy
    MartinCacao, A
    LopezGonzalez, MA
    Calvo, JR
    Giordano, M
    Guerrero, JM
    CHRONOBIOLOGY INTERNATIONAL, 1995, 12 (06) : 382 - 388
  • [3] Daily variations in 2-[I-125]melatonin specific binding in the golden hamster retina
    Faillace, MP
    delasHeras, MA
    Sarmiento, MIK
    Rosenstein, RE
    NEUROREPORT, 1995, 7 (01) : 141 - 144
  • [4] SEDATIVE POTENCY AND 2-[I-125]IODOMELATONIN BINDING-AFFINITY OF MELATONIN ANALOGS
    SUGDEN, D
    PSYCHOPHARMACOLOGY, 1995, 117 (03) : 364 - 370
  • [5] SPECIFIC BINDING OF 2-[I-125]IODOMELATONIN BY RAT SPLENOCYTES - CHARACTERIZATION AND ITS ROLE ON REGULATION OF CYCLIC-AMP PRODUCTION
    RAFIIELIDRISSI, M
    CALVO, JR
    POZO, D
    HARMOUCH, A
    GUERRERO, JM
    JOURNAL OF NEUROIMMUNOLOGY, 1995, 57 (1-2) : 171 - 178
  • [6] Specific binding of 2-[I-125]iodomelatonin by rat spleen crude membranes: Day-night variations and effect of pinealectomy and continuous light exposure
    RafiiElIdrissi, M
    Calvo, JR
    Giordano, M
    Guerrero, JM
    JOURNAL OF PINEAL RESEARCH, 1996, 20 (01) : 33 - 38
  • [7] Identification of 2-[125I] iodomelatonin binding sites in the thymus of mice and its significance
    刘志民
    赵瑛
    彭树勋
    Science in China(Series B), 1995, (12) : 1455 - 1461
  • [8] Identification and characterisation of 2-[I-125]iodomelatonin binding and Mel1a melatonin receptor expression in the human fetal leptomeninges
    Drew, JE
    Williams, LM
    Hannah, LT
    Barrett, P
    Abramovich, DR
    Morgan, PJ
    BRAIN RESEARCH, 1997, 761 (01) : 87 - 92
  • [9] 2-[I-125]iodo-5-methoxycarbonylamino-N-acetyltryptamine: A selective radioligand for the characterization of melatonin ML(2) binding sites
    Molinari, EJ
    North, PC
    Dubocovich, ML
    EUROPEAN JOURNAL OF PHARMACOLOGY, 1996, 301 (1-3) : 159 - 168
  • [10] PHOTOPERIODIC EFFECTS ON PUBERTY AND SPECIFIC 2-[I-125]IODOMELATONIN BINDING-SITES IN SIBERIAN HAMSTERS
    DUNCAN, MJ
    BRAIN RESEARCH, 1994, 640 (1-2) : 316 - 321
12345