HUD, A PARANEOPLASTIC ENCEPHALOMYELITIS ANTIGEN, CONTAINS RNA-BINDING DOMAINS AND IS HOMOLOGOUS TO ELAV AND SEX-LETHAL

被引：528

作者：

SZABO, A ^{[1
]}

DALMAU, J ^{[1
]}

MANLEY, G ^{[1
]}

ROSENFELD, M ^{[1
]}

WONG, E ^{[1
]}

HENSON, J ^{[1
]}

POSNER, JB ^{[1
]}

FURNEAUX, HM ^{[1
]}

机构：

[1] MEM SLOAN KETTERING CANC CTR,DEPT NEUROL,NEW YORK,NY 10021

来源：

CELL | 1991年 / 67卷 / 02期

关键词：

D O I：

10.1016/0092-8674(91)90184-Z

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A neuronal antigen (HuD) recognized by the sera of patients with antibody-associated paraneoplastic encephalomyelitis has been isolated by screening a lambda cerebellar expression library. The recombinant antigen provides an unambiguous assay for this rare condition associated with small cell lung cancer. The recombinant antigen has been used to identify specific infiltrating lymphocytes in tumors and affected brain tissues of patients with antibody-associated paraneoplastic encephalomyelitis and sensory neuronopathy. HuD mRNA is uniquely expressed in brain tissue. The HuD protein shows a remarkable homology to the Drosophila proteins Elav and Sex-lethal and is likely to play a role in neuron-specific RNA processing.

引用

页码：325 / 333

页数：9

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