EXPRESSION OF RAT STRIATAL D1 AND D2 DOPAMINE RECEPTOR MESSENGER-RNAS - ONTOGENIC AND PHARMACOLOGICAL STUDIES

被引:0
|
作者
CREESE, I [1 ]
SIBLEY, DR [1 ]
XU, SX [1 ]
机构
[1] NINCDS,EXPTL THERAPEUT BRANCH,BETHESDA,MD 20892
关键词
D O I
暂无
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
The developmental characteristics of D1 and D2 dopamine receptor mRNA levels were determined by Northern blot analyses. Striatal D1 and D2 receptor mRNAs of male Fischer 344 rats were about 60% of adults levels at postnatal day 1 and reached their highest measured levels at day 30 (126-139% adults levels) and then decreased by day 120 (100%). D1 and D2 receptor densities at day 30 were about 8-fold higher than at day 1, while mRNA levels showed only a 2-fold increase. The highest level of D2 receptor mRNA in midbrain as reached at day 14 (195% adult level) while levels at day 1 were 31% higher than dose at day 120. Treatment with selective D2 receptor antagonist, haloperidol (0.5 mg/kg/day, s.c., for 2 h, 7,14,21 days or 21 days + 3 days withdrawal) had no effect on Sprague-Dawley rat striatal D2 receptor mRNA levels in spite of significant increases in receptor density at the later time points. However, the selective D1 receptor antagonist, SCH 23390 (0.5 mg/kg/day, s.c.) produced increases in striatal D1 receptors and mRNA levels after treatments of 7,14 and 21 days + 3 days withdrawal.
引用
收藏
页码:S45 / S48
页数:4
相关论文
共 50 条
  • [31] Striatal dopamine D1 and D2 receptors in burning mouth syndrome
    Hagelberg, N
    Forssell, H
    Rinne, JO
    Scheinin, H
    Taiminen, T
    Aalto, S
    Luutonen, S
    Någren, K
    Jääskeläinen, S
    PAIN, 2003, 101 (1-2) : 149 - 154
  • [32] Effect of desipramine during infancy and preweanling on dorsal striatal dopamine D1 and D2 receptor binding in adolescence in the rat
    Hilakivi, I
    Rinne, J
    Marjamäki, P
    POLISH JOURNAL OF PHARMACOLOGY, 1999, 51 (04): : 311 - 316
  • [33] D2 receptor stimulation, but not D1, restores striatal equilibrium in a rat model of Parkinsonism
    Ballion, Berangere
    Frenois, Francois
    Zold, Camila L.
    Chetrit, Jonathan
    Murer, M. Gustavo
    Gonon, Francois
    NEUROBIOLOGY OF DISEASE, 2009, 35 (03) : 376 - 384
  • [34] Expression of D1 but not D2 dopamine receptors in striatal neurons producing neurokinin B in rats
    Sonomura, Takahiro
    Nakamura, Kouichi
    Furuta, Takahiro
    Hioki, Hiroyuki
    Nishi, Akinori
    Yamanaka, Atsushi
    Uemura, Masanori
    Kaneko, Takeshi
    EUROPEAN JOURNAL OF NEUROSCIENCE, 2007, 26 (11) : 3093 - 3103
  • [35] Cellular colocalization of dopamine D1 mRNA and D2 receptor in rat brain using A D2 dopamine receptor specific polyclonal antibody
    Maltais, S
    Côté, S
    Drolet, G
    Falardeau, S
    PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY, 2000, 24 (07): : 1127 - 1149
  • [36] Determination of D1 and D2 dopamine receptor expression by Ntera-2 cells
    Sakolsky, DJ
    Ashby, B
    MOLECULAR BRAIN RESEARCH, 2000, 84 (1-2): : 158 - 161
  • [37] Interactions of dopamine D1 and D2 receptor antagonists with D-methamphetamine-induced hyperthermia and striatal dopamine and serotonin reductions
    Broening, HW
    Morford, LL
    Vorhees, CV
    SYNAPSE, 2005, 56 (02) : 84 - 93
  • [39] Genetic variants of dopamine D2 receptor impact heterodimerization with dopamine D1 receptor
    Blasiak, Ewa
    Lukasiewicz, Sylwia
    Szafran-Pilch, Kinga
    Dziedzicka-Wasylewska, Marta
    PHARMACOLOGICAL REPORTS, 2017, 69 (02) : 235 - 241
  • [40] Localization of dopamine D1 and D2 receptor mRNAs in the rat systemic and pulmonary vasculatures
    Kim, MO
    Koh, PO
    Kim, JH
    Kim, JS
    Kang, SS
    Cho, GJ
    Kim, K
    Choi, WS
    MOLECULES AND CELLS, 1999, 9 (04) : 417 - 421