DETERMINATION OF ZOMEPIRAC IN PLASMA BY HIGH-PRESSURE LIQUID-CHROMATOGRAPHY

被引：22

作者：

NG, KT

SNYDERMAN, T

机构：

[1] McNeil Laboratories, Fort Washington, PA 19034

来源：

JOURNAL OF CHROMATOGRAPHY | 1979年 / 178卷 / 01期

关键词：

D O I：

10.1016/S0021-9673(00)89712-5

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

A sensitive, specific and precise high-pressure liquid-chromatographic method for the determination of the analgesic agent, zomepirac, in plasma samples is described. The lowest concentration of zomepirac that can be measured accurately and precisely (coefficient of variation <20%) in a 2-ml plasma sample is 10 ng/ml. The standard curve is linear in the concentration range of 10 to 5000 ng/ml. To date, this procedure has been employed successfully in analysing over 10,000 clinical plasma samples. © 1979.

引用

页码：241 / 247

页数：7