N-MYC SUPPRESSION AND CELL-CYCLE ARREST AT G1 PHASE BY PROSTAGLANDINS

被引：31
|
作者：
MARUI, N
SAKAI, T
HOSOKAWA, N
YOSHIDA, M
AOIKE, A
KAWAI, K
NISHINO, H
FUKUSHIMA, M
机构：
[1] KYOTO PREFECTURAL UNIV MED,DEPT BIOCHEM,KAMIKYO KU,KYOTO 602,JAPAN
[2] AICHI CANC CTR,DEPT INTERNAL MED,CHIKUSA KU,NAGOYA,AICHI 464,JAPAN
来源：
FEBS LETTERS | 1990年 / 270卷 / 1-2期
关键词：
Cell cycle; Human neuroblastoma cell; Prostaglandin A[!sub]2[!/sub] N-myc; Δ[!sup]12[!/sup]-Prostaglandin J[!sub]2[!/sub;
D O I：
10.1016/0014-5793(90)81224-C
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Effects of cyclopentenone prostaglandins, Δ12-prostaglandin (PG) J2 and PGA2 on the expression of N-myc in relation to the effects on cell cycle progression were investigated using human neuroblastoma cell line GOTO. Both PGs suppressed M-myc expression within several hours prior to inducing G1 arrest. The N-myc suppression with Δ12-PGJ2 was continued but with PGA2 it was gradually released, followed by the release of G1 arrest. These results suggest that Δ12-PGJ2 and PGA2 inhibit cell cycle progression in strong association with N-myc suppression and Δ12-PGJ2 is more potent and has a longer effect than PGA2. © 1990.
引用
收藏
页码：15 / 18
页数：4
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