N-MYC SUPPRESSION AND CELL-CYCLE ARREST AT G1 PHASE BY PROSTAGLANDINS

被引：31

作者：

MARUI, N

SAKAI, T

HOSOKAWA, N

YOSHIDA, M

AOIKE, A

KAWAI, K

NISHINO, H

FUKUSHIMA, M

机构：

[1] KYOTO PREFECTURAL UNIV MED,DEPT BIOCHEM,KAMIKYO KU,KYOTO 602,JAPAN

[2] AICHI CANC CTR,DEPT INTERNAL MED,CHIKUSA KU,NAGOYA,AICHI 464,JAPAN

来源：

FEBS LETTERS | 1990年 / 270卷 / 1-2期

关键词：

Cell cycle; Human neuroblastoma cell; Prostaglandin A[!sub]2[!/sub] N-myc; Δ[!sup]12[!/sup]-Prostaglandin J[!sub]2[!/sub;

D O I：

10.1016/0014-5793(90)81224-C

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Effects of cyclopentenone prostaglandins, Δ12-prostaglandin (PG) J2 and PGA2 on the expression of N-myc in relation to the effects on cell cycle progression were investigated using human neuroblastoma cell line GOTO. Both PGs suppressed M-myc expression within several hours prior to inducing G1 arrest. The N-myc suppression with Δ12-PGJ2 was continued but with PGA2 it was gradually released, followed by the release of G1 arrest. These results suggest that Δ12-PGJ2 and PGA2 inhibit cell cycle progression in strong association with N-myc suppression and Δ12-PGJ2 is more potent and has a longer effect than PGA2. © 1990.

引用

页码：15 / 18

页数：4

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