LOCALIZATION AND VERIFICATION BY SYNTHESIS OF 5 ANTIGENIC SITES OF BOVINE SERUM-ALBUMIN

被引：52
作者：
ATASSI, MZ
SAKATA, S
KAZIM, AL
机构：
来源：
BIOCHEMICAL JOURNAL | 1979年 / 179卷 / 02期
关键词：
D O I：
10.1042/bj1790327
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Recently we have shown that the major antigenic sites of bovine serum albumin exhibit functional equivalence progessively increasing with the time at which antibodies are obtained after the first immunization. Analysis of our recent immunochemical findings and the known covalent structure of bovine serum albumin have enabled us to predict the locations of five antigenic sites of bovine serum albumin. The predicted locations were synthesized, and immunochemical studies with late-course antisera showed them to constitute antigenic sites of native bovine serum albumin.
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页码：327 / 331
页数：5
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