Rapid desensitization to isoniazid and rifampin in an adolescent with active pulmonary tuberculosis

被引：1

作者：

Lee, Heirim ^{[1
]}

Kim, Min-Sun ^{[1
]}

Yang, Hea-Kyoung ^{[1
]}

Kim, Minji ^{[1
]}

Lee, Ji Young ^{[1
]}

Kim, Jong-Min ^{[1
]}

Kang, Ji-Man ^{[1
]}

Kim, Yae-Jean ^{[1
]}

Ahn, Kangmo ^{[1
]}

Kim, Jihyun ^{[1
]}

机构：

[1] Sungkyunkwan Univ, Dept Pediat, Samsung Med Ctr, Sch Med, 81 Irwon Ro, Seoul 06351, South Korea

来源：

ALLERGY ASTHMA & RESPIRATORY DISEASE | 2016年 / 4卷 / 03期

关键词：

Immunologic desensitization; Antitubercular agents; Drug hypersensitivity;

D O I：

10.4168/aard.2016.4.3.212

中图分类号：

R392 [医学免疫学];

学科分类号：

100102 ;

摘要：

Hypersensitivity reactions to antituberculosis medicine are obstacles to the treatment of tuberculosis. However, rapid drug desensitization can secure successful treatment with essential antituberculosis medicines in pediatric patients. A 17-year-old boy with active pulmonary tuberculosis complained of generalized erythematous rashes, pruritus on the 11th day of tuberculosis treatment. He was diagnosed with hypersensitivity reactions to isoniazid and rifampin by the oral provocation test. After desensitization, the patient continued to take antituberculosis treatment with isoniazid, rifampin, pyrazinamide, and ethambutol. We report here a case of successful desensitization in an adolescent with hypersensitivity to isoniazid and rifampin.

引用

页码：212 / 216

页数：5

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