SYNTHESIS OF DERIVATIVES OF THIAZOLO[4,5-D]PYRIMIDINE .I.

被引：16

作者：

BAKER, JA

CHATFIELD, PV

机构：

[1] School of Pharmacy, Brighton College of Technology, Moulescoomb, Brighton

来源：

JOURNAL OF THE CHEMICAL SOCIETY C-ORGANIC | 1969年 / 04期

关键词：

D O I：

10.1039/j39690000603

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Reaction of 2,4-diamino-5-bromo-6-hydroxypyrimidine with thiourea gave the isothiouronium salt, which with alkali afforded di-(2,4-diamino-6- hydroxypyrimidin-5-yl) disulphide and not the thiazolo[4,5-d]pyrimidine claimed by an earlier worker. Kaufmann thiocyanation of 2,4-diamino-6-hydroxypyrimidine yielded the 5-thiocyanato-compound, which did not readily cyclise to a thiazolo[4,5-d]pyrimidine as previously claimed by other workers. Cyclisation of the thiocyanato-compound has been effected with acetic anhydride. Deacetylation of the resulting diacetamido-derivative gave 2,5-diamino-7-hydroxythiazolo[4,5- d]pyrimidine.

引用

页码：603 / +

页数：1