MOLECULAR PATHOLOGY OF HUMAN NEUROBLASTOMAS

被引：0

作者：

BRODEUR, GM

机构：

来源：

SEMINARS IN DIAGNOSTIC PATHOLOGY | 1994年 / 11卷 / 02期

关键词：

NEUROBLASTOMA; GENETICS; CYTOGENETICS; MOLECULAR GENETICS; DELETION OF CHROMOSOME 1P; DOUBLE-MINUTE CHROMATIN BODIES; HOMOGENEOUSLY STAINING REGION; TUMOR CELL DNA CONTENT; PLOIDY; NEAR-DIPLOID; NEAR-TRIPLOID; NEAR-TETRAPLOID; ONCOGENES; N-MYC; AMPLIFICATION; SUPPRESSOR GENES; RESTRICTION FRAGMENT LENGTH POLYMORPHISM; LOSS OF HETEROZYGOSITY; PROGNOSTIC FACTORS; POLYMERASE CHAIN REACTION; NERVE GROWTH FACTOR; NERVE GROWTH FACTOR RECEPTOR;

D O I：

暂无

中图分类号：

R446 [实验室诊断]; R-33 [实验医学、医学实验];

学科分类号：

1001 ;

摘要：

Several genetic features have been identified that are characteristic of neuroblastomas. These include hyperdiploidy, deletion of 1p, amplification of N-myc, and expression of the neurotrophin receptor, TRK-A. These genetic characteristics allow neuroblastomas to be categorized into three subtypes, with distinct clinical features and behavior. In the past, neuroblastoma had been considered to be a disease with a better outcome if diagnosed early. However, it is now apparent that the tumors occurring in infants are genetically different than those in older children, and a genetically favorable subtype seldom, if ever, evolves into an unfavorable one. Different approaches may be necessary for each subtype, and the molecular pathology of the tumor may be better at predicting outcome than patient age and disease stage. Copyright (C) 1994 by W.B. Saunders Company

引用

页码：118 / 125

页数：8