COADAPTATION AND IMMUNODEFICIENCY VIRUS - LESSONS FROM THE FELIDAE

被引：61
作者：
CARPENTER, MA
OBRIEN, SJ
机构：
[1] MA Carpenter and SJ O'Brien, Laboratory of Viral Carcinogenesis, NCI-FCRDC, Frederick, MD 21702-1201, PO Box B
来源：
CURRENT OPINION IN GENETICS & DEVELOPMENT | 1995年 / 5卷 / 06期
关键词：
D O I：
10.1016/0959-437X(95)80006-Q
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
The emergence of pathogenic viruses in new species offers an unusual opportunity to monitor the coadaptation of viruses and their hosts in a dynamic ongoing process of intense biological selection. Tracking lentivirus epidemics in man, monkeys and cats reveals genomic struggles at three levels: quasispecies divergence within an individual; coadaptation of virus and host genomes subsequent to disease outbreaks; and transmission, spread and pathogenesis in related host species. Aspects of each level are revealed by examining the genetic diversity of feline immunodeficiency virus in domestic and wild cat species. This approach has been facilitated by the recent genetic characterization of a novel lentivirus in lions.
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页码：739 / 745
页数：7
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