REGULATION OF PML MESSENGER-RNA EXPRESSION IN HUMAN BREAST-CARCINOMA CELLS

被引：0
作者：
LI, XS
SHEIKH, MS
SHAO, ZM
LANZKRON, S
CHEN, JC
FONTANA, JA
机构：
[1] UNIV MARYLAND, SCH MED, CTR CANC, BALTIMORE, MD 21201 USA
[2] UNIV MARYLAND, SCH MED, DEPT MED, DIV ONCOL, BALTIMORE, MD 21201 USA
[3] VET ADM MED CTR, BALTIMORE, MD 21201 USA
来源：
INTERNATIONAL JOURNAL OF ONCOLOGY | 1994年 / 5卷 / 05期
关键词：
PML; HBC; CELL CYCLE;
D O I：
暂无
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
We examined the mRNA expression profile of PML, a novel nuclear protein recently characterized from acute promyelocytic leukemia (APL) blast cells, in a number of breast carcinoma cell lines. PML mRNA was found to be differentially expressed among the cell lines examined. A correlation of borderline significance between PML mRNA expression and the proliferative capacity of the cell Lines was noted. Serum stimulation significantly elevated the PML mRNA levels in the T47D and MDA-MB-231 cells. These results would suggest that PML may function as a positive regulator of cellular proliferation in breast carcinoma cells.
引用
收藏
页码：1177 / 1181
页数：5
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