The impact of fibroblast growth factor-23 on the cardiovascular system in chronic kidney disease

被引：1

作者：

Lee, Gavin ^{[1
]}

Krishnasamy, Rathika ^{[1
,2
]}

Hawley, Carmel M. ^{[1
,2
,3
]}

Johnson, David W. ^{[1
,2
,3
]}

机构：

[1] Princess Alexandra Hosp, Dept Nephrol, Brisbane, Qld, Australia

[2] Univ Queensland, Sch Med, Brisbane, Qld, Australia

[3] Translat Res Inst, Brisbane, Qld, Australia

来源：

EXPERT REVIEW OF ENDOCRINOLOGY & METABOLISM | 2015年 / 10卷 / 06期

关键词：

cardiovascular disease; chronic kidney disease; endothelial function; fibroblast growth factor-23; klotho; left ventricular hypertrophy; secondary hyperparathyroidism; vascular calcification;

D O I：

10.1586/17446651.2015.1079124

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Chronic kidney disease is associated with an accelerated risk of cardiovascular (CV) mortality. Seminal work over the last decade has identified abnormal bone metabolism as an important modulator of the increased CV burden in this cohort. In particular, FGF23, a phosphaturic hormone with serum levels found to be markedly elevated in chronic kidney disease, is independently associated with increased risks of all-cause mortality and CV events. This editorial will discuss the proposed mechanisms linking FGF23 to CV disease in chronic kidney disease, namely, direct cardiac myocyte toxicity, endothelial dysfunction and vascular calcification.

引用

页码：565 / 568

页数：4

共 29 条

[1] Fibroblast Growth Factor-23 and Cardiac Structure and Function [J].

Agarwal, Isha ;

Ide, Noriko ;

Ix, Joachim H. ;

Kestenbaum, Bryan ;

Lanske, Beate ;

Schiller, Nelson B. ;

Whooley, Mary A. ;

Mukamal, Kenneth J. .

JOURNAL OF THE AMERICAN HEART ASSOCIATION, 2014, 3 (01) :e000584

[2] Fibroblast Growth Factor-23 Levels Are Associated with Vascular Calcifications in Peritoneal Dialysis Patients [J].

Asicioglu, Ebru ;

Kahveci, Arzu ;

Arikan, Hakki ;

Koc, Mehmet ;

Tuglular, Serhan ;

Ozener, Cetin Ishak .

NEPHRON CLINICAL PRACTICE, 2013, 124 (1-2) :89-93

[3] Mineral metabolism parameters throughout chronic kidney disease stages 1-5 -: achievement of K/DOQI target ranges [J].

Craver, Lourdes ;

Paz Marco, Maria ;

Martinez, Isabel ;

Rue, Montserrat ;

Borras, Merce ;

Luisa Martin, Maria ;

Sarro, Felipe ;

Manuel Valdivielso, Jose ;

Fernandez, Elvira .

NEPHROLOGY DIALYSIS TRANSPLANTATION, 2007, 22 (04) :1171-1176

[4] FGF23 induces left ventricular hypertrophy [J].

Faul, Christian ;

Amaral, Ansel P. ;

Oskouei, Behzad ;

Hu, Ming-Chang ;

Sloan, Alexis ;

Isakova, Tamara ;

Gutierrez, Orlando M. ;

Aguillon-Prada, Robier ;

Lincoln, Joy ;

Hare, Joshua M. ;

Mundel, Peter ;

Morales, Azorides ;

Scialla, Julia ;

Fischer, Michael ;

Soliman, Elsayed Z. ;

Chen, Jing ;

Go, Alan S. ;

Rosas, Sylvia E. ;

Nessel, Lisa ;

Townsend, Raymond R. ;

Feldman, Harold I. ;

Sutton, Martin St. John ;

Ojo, Akinlolu ;

Gadegbeku, Crystal ;

Di Marco, Giovana Seno ;

Reuter, Stefan ;

Kentrup, Dominik ;

Tiemann, Klaus ;

Brand, Marcus ;

Hill, Joseph A. ;

Moe, Orson W. ;

Kuro-o, Makoto ;

Kusek, John W. ;

Keane, Martin G. ;

Wolf, Myles .

JOURNAL OF CLINICAL INVESTIGATION, 2011, 121 (11) :4393-4408

[5] Fibroblast growth factor 23 in acute myocardial infarction complicated by cardiogenic shock: a biomarker substudy of the Intraaortic Balloon Pump in Cardiogenic Shock II (IABP-SHOCK II) trial [J].

Fuernau, Georg ;

Poess, Janine ;

Denks, Daniel ;

Desch, Steffen ;

Heine, Gunnar H. ;

Eitel, Ingo ;

Seiler, Sarah ;

de Waha, Suzanne ;

Ewen, Sebastian ;

Link, Andreas ;

Schuler, Gerhard ;

Adams, Volker ;

Boehm, Michael ;

Thiele, Holger .

CRITICAL CARE, 2014, 18 (06)

[6] Chronic kidney disease and cardiovascular risk: epidemiology, mechanisms, and prevention [J].

Gansevoort, Ron T. ;

Correa-Rotter, Ricardo ;

Hemmelgarn, Brenda R. ;

Jafar, Tazeen H. ;

Heerspink, Hiddo J. Lambers ;

Mann, Johannes F. ;

Matsushita, Kunihiro ;

Wen, Chi Pang .

LANCET, 2013, 382 (9889) :339-352

[7] Fibroblast growth factor 23 and mortality among patients undergoing hemodialysis [J].

Gutierrez, Orlando M. ;

Mannstadt, Michael ;

Isakova, Tamara ;

Rauh-Hain, Jose Alejandro ;

Tamez, Hector ;

Shah, Anand ;

Smith, Kelsey ;

Lee, Hang ;

Thadhani, Ravi ;

Juppner, Harald ;

Wolf, Myles .

NEW ENGLAND JOURNAL OF MEDICINE, 2008, 359 (06) :584-592

[8] Direct evidence for a causative role of FGF23 in the abnormal renal phosphate handling and vitamin D metabolism in rats with early-stage chronic kidney disease [J].

Hasegawa, Hisashi ;

Nagano, Nobuo ;

Urakawa, Itaru ;

Yamazaki, Yuji ;

Iijima, Kousuke ;

Fujita, Toshiro ;

Yamashita, Takeyoshi ;

Fukumoto, Seiji ;

Shimada, Takashi .

KIDNEY INTERNATIONAL, 2010, 78 (10) :975-980

[9] Serum Phosphorus Concentrations and Arterial Stiffness among Individuals with Normal Kidney Function to Moderate Kidney Disease in MESA [J].

Ix, Joachim H. ;

De Boer, Ian H. ;

Peralta, Carmen A. ;

Adeney, Kathryn L. ;

Duprez, Daniel A. ;

Jenny, Nancy S. ;

Siscovick, David S. ;

Kestenbaum, Bryan R. .

CLINICAL JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY, 2009, 4 (03) :609-615

[10]

Kaisar M, 2007, Minerva Urol Nefrol, V59, P281

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