BASAL AND THROMBIN-STIMULATED PLATELET CELL CALCIUM

被引：0
|
作者：
DWYER, TM
DIVEKI, K
NEWTON, G
SZEBENI, A
HILDEBRANDT, D
PETRINI, M
机构：
[1] Departments of Physiology and Biophysics and Medicine (MP), University of Mississippi Medical Center, Jackson, MS
来源：
AMERICAN JOURNAL OF HYPERTENSION | 1994年 / 7卷 / 03期
关键词：
PLATELET; CALCIUM; THROMBIN; HYPERTENSION; DOG; FURA-2;
D O I：
10.1093/ajh/7.3.261
中图分类号：
R6 [外科学];
学科分类号：
1002 ; 100210 ;
摘要：
To study platelet cell calcium in dogs, we measured the fura-2-determined calcium concentration (Ca-i) in platelets derived from blood drawn through indwelling arterial catheters in four dogs. Platelet samples were obtained 3 days a week for 39 days. Canine platelet Ca-i averages 40.5 +/- 1.7 nmol/L when corrected for extracellular fura-2 dye (n = 46); this mean is significantly smaller than the value obtained without such a correction (50.2 +/- 2.0 nmol/L, P<.05). The amplitude of thrombin-induced Ca2+ transients is proportional to basal Ca-i increasing 4.9 +/- 0.9 nmol/L peak Ca2+ per nmol/L increase in baseline Ca2+.
引用
收藏
页码：261 / 268
页数：8
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