SELECTIVE TRANSPORT OF AMINO-ACIDS ACROSS A CROSS-LINKED POLY(L-GLUTAMIC ACID) MEMBRANE

被引：4

作者：

SATO, M ^{[1
]}

ICHIGE, A ^{[1
]}

EMURA, T ^{[1
]}

YOSHIMOTO, M ^{[1
]}

NAKAHIRA, T ^{[1
]}

IWABUCHI, S ^{[1
]}

KOJIMA, K ^{[1
]}

机构：

[1] CHIBA UNIV,FAC ENGN,DEPT APPL CHEM,YAYOI CHO 1-33,CHIBA 260,JAPAN

来源：

POLYMER | 1993年 / 34卷 / 06期

关键词：

POLY(L-GLUTAMIC ACID); CROSS-LINKING; AMINO ACIDS; PERMSELECTIVITY; PH DEPENDENCE;

D O I：

10.1016/0032-3861(93)90779-A

中图分类号：

O63 [高分子化学（高聚物）];

学科分类号：

070305 ; 080501 ; 081704 ;

摘要：

Poly(L-glutamic acid) (PLG) membranes were prepared by crosslinking poly[gamma-(2-chloroethyl) L-glutamate] with diethylenetriamine and subsequently hydrolysing the side-chain esters. Selective amino acid transport across the membrane was examined using L-phenylglycine, L-phenylalanine and L-tryptophan. Transport selectivity increased with increasing pH of the solute solution, i.e. from 2.0 to 5.7. When pH was raised to 8.0 or when CaCl2 was added, transport selectivity was lost. Conformational changes of PLG and electrostatic interactions between the solute and the membrane are suggested to cause the observed permselectivity behaviour.

引用

页码：1237 / 1239

页数：3