PREPARATION OF [CYS(2)]-RA-VII - THE 1ST SULFUR-CONTAINING ANALOG OF RAS POSSESSING ANTITUMOR-ACTIVITY - STUDIES ON RA DERIVATIVES .3.

被引：10

作者：

ITOKAWA, H

KONDO, K

HITOTSUYANAGI, Y

TAKEYA, K

机构：

[1] Department of Pharmacognosy, Tokyo College of Pharmacy Horinouchi, Hachioji, Tokyo

来源：

HETEROCYCLES | 1993年 / 36卷 / 08期

关键词：

D O I：

10.3987/COM-93-6382

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

RA-III (2), a potent antitumor cyclic hexapeptide, has been converted to [Cys2]-RA-VII (5) via thiolacetate (3). Derivatives (3) and (5) showed antitumor activities against P388 leukemia cells in vitro and in vivo.

引用

页码：1837 / 1843

页数：7