DIFFUSION BEHAVIOR OF KETOPROFEN THROUGH CHITOSAN-ALGINATE MEMBRANES

Chitosan-alginate membrane diffusion behavior has been investigated for its application in drugs delivery system. Ketoprofen diffusion behavior assay were performed at 37 and 42(circle)C to membrane thickness (h) and donor cell concentration of ketoprofen variations (A). The results showed that equilibrium concentrations (C-s) of ketoprofen equation was 27.0087 + 0.09067T - 1.7499h + 0.1030A + 0.0161h(2) - 0.0022A(2) + 0.0040Th - 0.0018TA + 0.0095hA. The value of C-s was closer to the expected therapy concentration at 50 and 75 mg/L with thin membrane (10-34 mu m). Based on Higuchi equation, the model for J and D were J = 11.0849 - 0.2713T - 0.3132h - 0.7461C(s) - 0.0096A - 0.0001h(2) - 0.0131C(s)(2) + 0.0002A(2) + 0.0084Th + 0.0275TC(s) - 0.0018TA - 0.0059hC(s) + 0.0021hA + 0.0037C(s)A with R-2 = 97.9% and D = - 12.5000 + 0.2266T + 0.1313h + 0.1538C(s) + 0.1200A - 0.0009h(2) + 0.0240 C-s(2) - 0.0009A(2 +) 0.0015Th - 0.0150 TCs - 0.0011TA - 0.0096hC(s) + 0.0004hA + 0.0039C(s)A with R-2 = 98.7%, respectively. The two dimensional contour maps of J versus A and h, both at 37 and 42(circle)C, showed an increasing of J value as A, h, or T increased.