INVERTEBRATE PHARMACOLOGICAL ASSAY OF NOVEL, POTENT GLUTAMATE RECEPTOR ANTAGONISTS - ACYLATED SPERMINES

被引：19
作者：
BLAGBROUGH, IS
BRUCE, M
BYCROFT, BW
MATHER, AJ
USHERWOOD, PNR
机构：
[1] UNIV NOTTINGHAM,DEPT PHARMACEUT SCI,NOTTINGHAM NG7 2RD,ENGLAND
[2] UNIV NOTTINGHAM,DEPT ZOOL,NOTTINGHAM NG7 2RD,ENGLAND
来源：
PESTICIDE SCIENCE | 1990年 / 30卷 / 04期
关键词：
D O I：
10.1002/ps.2780300404
中图分类号：
S3 [农学（农艺学）];
学科分类号：
0901 ;
摘要：
Synthetic analogues of arthropod polyamine-containing toxins have been investigated for antagonism of the quisqualate-sensitive L-glutamate receptor (quis-GluR) of locust muscle. Block of the cation-selective channel gated by quis-GluR was demonstrated for N-(4-hydroxyphenylpropanoyl)-and N-(4-hydroxyphenylacetyl)-spermine at significantly lower concentrations than that for spermine.
引用
收藏
页码：397 / 403
页数：7
相关论文
共 16 条
[1]   POSTSYNAPTIC BLOCK OF A GLUTAMATERGIC SYNAPSE BY LOW-MOLECULAR WEIGHT FRACTIONS OF SPIDER VENOM [J].
BATEMAN, A ;
BODEN, P ;
DELL, A ;
DUCE, IR ;
QUICKE, DLJ ;
USHERWOOD, PNR .
BRAIN RESEARCH, 1985, 339 (02) :237-244
[2]   INVERTEBRATE PHARMACOLOGICAL ASSAY OF NOVEL, POTENT GLUTAMATE RECEPTOR ANTAGONISTS - ACYLATED SPERMINES [J].
BLAGBROUGH, IS ;
BRUCE, M ;
BYCROFT, BW ;
MATHER, AJ ;
USHERWOOD, PNR .
PESTICIDE SCIENCE, 1990, 30 (04) :397-403
[3]  
BLAGBROUGH IS, 1989, J PHARM PHARM SUPPL, V41
[4]  
BRUCE M, 1990, IN PRESS TOXICON
[5]   RELATIVE TROPHIC INFLUENCES OF EXCITATORY AND INHIBITORY INNERVATION OF LOCUST SKELETAL-MUSCLE FIBERS [J].
CLARK, RB ;
GRATION, KAF ;
USHERWOOD, PNR .
NATURE, 1979, 280 (5724) :679-682
[6]   STRUCTURE AND SYNTHESIS OF A POTENT GLUTAMATE RECEPTOR ANTAGONIST IN WASP VENOM [J].
ELDEFRAWI, AT ;
ELDEFRAWI, ME ;
KONNO, K ;
MANSOUR, NA ;
NAKANISHI, K ;
OLTZ, E ;
USHERWOOD, PNR .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1988, 85 (13) :4910-4913
[7]   SPIDER TOXINS AS TOOLS FOR DISSECTING ELEMENTS OF EXCITATORY AMINO-ACID TRANSMISSION [J].
JACKSON, H ;
USHERWOOD, PNR .
TRENDS IN NEUROSCIENCES, 1988, 11 (06) :278-283
[8]  
PIEK T, 1985, COMPREHENSIVE INSECT, V11, P55
[9]  
USHERWOOD PN, 1968, J EXP BIOL, V49, P341
[10]  
USHERWOOD PN, 1967, AM ZOOL, V7, P553
12