Antioxidant, antimicrobial and antibiotic resistance modifying effect of Heliotropium indicum

The present study is based on the determination of phytochemical, antimicrobial, anti-oxidant and antibiotic resistance modifying activities of soil grown Heliotropium indicum. The phytochemical screening showed the presence of Tannin, Oxalate, Phytate, Terpenoids, Trypsin inhibitors, Phenol, Carotenoids, Carotene, Xanthophyll, Flavonoid, Saponin, and Alkaloids. Acetone extracts by paper disc and open well method showed highest antimicrobial activity against different pathogens which was followed by ethanol extract. Lowest MIC was also shown by acetone, followed by ethanol. Fractional inhibitory concentration was also determined, in which acetone and ethanol generally showed synergistic effect compared to aqueous extract which showed mostly additive effect. As the concentration of the plant extract increased, antioxidant activity also increased. Acetone was able to show highest activity of antioxidants compared to other solvents. Based on the above facts, it is concluded that the extract can be used as an antimicrobial, antioxidant and antibiotic resistance modifying agent.