HUMAN T-CELL RESPONSE TO THE SURFACE-ANTIGEN OF HEPATITIS-B VIRUS (HBSAG) - ENDOSOMAL AND NONENDOSOMAL PROCESSING PATHWAYS ARE ACCESSIBLE TO BOTH ENDOGENOUS AND EXOGENOUS ANTIGEN

被引：197

作者：

JIN, Y ^{[1
]}

SHIH, JWK ^{[1
]}

BERKOWER, I ^{[1
]}

机构：

[1] NIH, DEPT TRANSFUS MED, BETHESDA, MD 20892 USA

来源：

JOURNAL OF EXPERIMENTAL MEDICINE | 1988年 / 168卷 / 01期

关键词：

D O I：

10.1084/jem.168.1.293

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

We have studied the antigen specificity and processing requirements of three vaccine-induced cloned human T cell lines specific for HBsAg, the envelope protein of hepatitis B virus. Each T cell line recognized endogenously expressed antigen as well as exogenous antigen. Two clones required endosomal processing, both for exogenous and endogenous antigen; while the other T cell line depended on nonendosomal processing to generate antigenic peptides from both endogenous and exogenous antigen. Thus, the two processing pathways are accessible to exogenous and endogenous antigen. These results suggest that vaccine-induced T cells can participate actively in the immune response to live virus.

引用

页码：293 / 306

页数：14

共 39 条

[1] IDENTIFICATION OF THE T-CELL AND IA CONTACT RESIDUES OF A T-CELL ANTIGENIC EPITOPE [J].