THALIDOMIDE IS AN INHIBITOR OF ANGIOGENESIS

被引：2045

作者：

DAMATO, RJ

LOUGHNAN, MS

FLYNN, E

FOLKMAN, J

机构：

[1] Department of Surgery, Children's Hospital, Harvard Medical School, Boston

来源：

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 1994年 / 91卷 / 09期

关键词：

FIBROBLAST GROWTH FACTOR; RABBIT CORNEA;

D O I：

10.1073/pnas.91.9.4082

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Thalidomide is a potent teratogen causing dysmelia (stunted limb growth) in humans. We have demonstrated that orally administered thalidomide is an inhibitor of angiogenesis induced by basic fibroblast growth factor in a rabbit cornea micropocket assay. Experiments including the analysis of thalidomide analogs revealed that the antiangiogenic activity correlated with the teratogenicity but not with the sedative or the mild immunosuppressive properties of thalidomide. Electron microscopic examination of the corneal neovascularization of thalidomide-treated rabbits revealed specific ultrastructural changes similar to those seen in the deformed limb bud vasculature of thalidomide-treated embryos. These experiments shed light on the mechanism of thalidomide's teratogenicity and hold promise for the potential use of thalidomide as an orally administered drug for the treatment of many diverse diseases dependent on angiogenesis.

引用

页码：4082 / 4085

页数：4

共 29 条

[1] SIMPLE PROCEDURE FOR LONG-TERM CULTIVATION OF CHICKEN EMBRYOS [J].