ATTENUATION OF HIPPOCAMPAL KAINIC ACID-INDUCED SEIZURES BY SUBSTANCE-P TREATMENT

被引：7
|
作者：
KLAPDOR, K
SPRICK, U
HUSTON, JP
机构：
[1] UNIV DUSSELDORF,INST PHYSIOL PSYCHOL 1,D-40225 DUSSELDORF,GERMANY
[2] UNIV DUSSELDORF,C&O VOGT INST BRAIN RES,D-40225 DUSSELDORF,GERMANY
来源：
PEPTIDES | 1994年 / 15卷 / 03期
关键词：
SUBSTANCE P; KAINIC ACID; SEIZURES; EPILEPSY;
D O I：
10.1016/0196-9781(94)90199-6
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Adult male Wistar rats (n = 21) received bilateral kainic acid lesions of their hippocampi. Over a period of 9 weeks the animals received daily IP injections of either 5 mu g/kg or 50 mu g/kg substance P (SP) or vehicle. Seizures provoked by the lesions were suppressed by the daily administration of the neuropeptide SP in a dose of 50 mu g/kg for the whole period of observation. The neurokinin significantly (p < 0.01) reduced the number of seizures compared to the vehicle-treated animals.
引用
收藏
页码：425 / 427
页数：3
相关论文
共 50 条
  • [1] POSSIBLE ROLE OF THE N-TERMINUS OF SUBSTANCE-P IN KAINIC ACID-INDUCED TOXICITY IN RATS
    VELAZQUEZ, RA
    SUN, XF
    KURTZ, HJ
    LARSON, AA
    BRAIN RESEARCH, 1993, 624 (1-2) : 109 - 114
  • [2] Kainic acid-induced dorsal and ventral hippocampal seizures in rats
    Akaike, K
    Tanaka, S
    Tojo, H
    Fukumoto, S
    Imamura, S
    Takigawa, M
    BRAIN RESEARCH, 2001, 900 (01) : 65 - 71
  • [3] Effect of thiamazole on kainic acid-induced seizures in mice
    Feng, Jigao
    Hao, Zheng
    Zhang, Xian
    Li, Mingxia
    Zhong, Wuzhao
    Zhang, Caicai
    Gharawi, Ali
    Alrashood, Sara T.
    Khan, Haseeb A.
    SAUDI JOURNAL OF BIOLOGICAL SCIENCES, 2021, 28 (03) : 1840 - 1846
  • [4] Interleukin-21 expression in hippocampal astrocytes is enhanced following kainic acid-induced seizures
    Xiong, Xiao-Yi
    Wang, Ting-Gang
    Yang, Mei-Hua
    Meng, Zhao-You
    Yang, Qing-Wu
    Wang, Fa-Xiang
    NEUROLOGICAL RESEARCH, 2016, 38 (02) : 151 - 157
  • [5] Hippocampal transection attenuates kainic acid-induced amygdalar seizures in rats
    Imamura, S
    Tanaka, S
    Akaike, K
    Tojo, H
    Takigawa, M
    Kuratsu, J
    BRAIN RESEARCH, 2001, 897 (1-2) : 93 - 103
  • [6] Kainic acid-induced seizures in the common marmoset
    Ishikawa, Akiyoshi
    Mizuno, Yuri
    Sakai, Keita
    Maki, Takehiro
    Tanaka, Ryo
    Oda, Yasuhiro
    Niimi, Kimie
    Takahashi, Eiki
    BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2020, 525 (03) : 595 - 599
  • [7] DAPSONE ATTENUATES KAINIC ACID-INDUCED SEIZURES IN RATS
    ALTAGRACIA, M
    MONROYNOYOLA, A
    OSORIORICO, L
    KRAVZOV, J
    ALVARADOCALVILLO, R
    MANJARREZMARMOLEJO, J
    RIOS, C
    NEUROSCIENCE LETTERS, 1994, 176 (01) : 52 - 54
  • [8] Decursin attenuates kainic acid-induced seizures in mice
    Lee, Jong-Keun
    Jeong, Ji Woon
    Jang, Taeik
    Lee, Go-Woon
    Han, Hogyu
    Kang, Jae-Seon
    Kim, Ik-Hwan
    NEUROREPORT, 2014, 25 (16) : 1243 - 1249
  • [9] EFFECT OF TEMPERATURE ON KAINIC ACID-INDUCED SEIZURES
    LIU, Z
    GATT, A
    MIKATI, M
    HOLMES, GL
    BRAIN RESEARCH, 1993, 631 (01) : 51 - 58
  • [10] ALTERED GABAERGIC EFFECTS ON KAINIC ACID-INDUCED SEIZURES IN THE PRESENCE OF HIPPOCAMPAL SCLEROSIS IN RATS
    ARAKI, T
    KATO, M
    GOTO, I
    BRAIN RESEARCH, 1994, 653 (1-2) : 237 - 242
12345