EXPOSURE TO MIXTURES AND CONGENERS OF POLYCHLORINATED-BIPHENYLS

被引:0
作者
SKERFVING, S [1 ]
SVENSSON, BG [1 ]
ASPLUND, L [1 ]
HAGMAR, L [1 ]
机构
[1] STOCKHOLM UNIV,INST APPL ENVIRONM RES,ANALYT ENVIRONM CHEM LAB,S-17185 SOLNA,SWEDEN
关键词
BLOOD; BREAST MILK; ADIPOSE TISSUE; FISH; TOXICOLOGY; ENVIRONMENTAL HAZARDS;
D O I
暂无
中图分类号
R446 [实验室诊断]; R-33 [实验医学、医学实验];
学科分类号
1001 ;
摘要
There are 209 congeners of polychlorinated biphenyls (PCBs), the metabolism and toxicity of which vary by congeners. Use of PCBs is now restricted, but environmental contamination and human exposure persist. Analysis for ''total PCBs'' in biological samples gives limited information; congener-specific analysis is far more informative, but more complicated. Concentrations of congeners in serum/plasma, adipose tissue, or milk are useful biomarkers of exposure. Lipids may contain similar concentrations and congener patterns, but these vary between exposures and are different from those of the corresponding exposure mixtures; hence, analysis of lipids cannot be used to identify the original exposure. Some non- and mono-ortho congeners may attain a coplanar conformation, which renders them capable of a dioxin-like action. Toxic equivalency factors (TEFs) have been used to sum that risk as toxic equivalents (TEQs), which are considerably different from congener concentrations. No reliable data have been developed on the relationship between concentrations of ''total PCBs'' or congeners in biological samples and effects of PCBs on human health, mainly because of the various analytical procedures involved and confounding exposures.
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页码:1409 / 1415
页数:7
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