ANTIBODIES TO PLATELET-ACTIVATING-FACTOR (PAF) INHIBIT PAF-INDUCED PLATELET-AGGREGATION

被引：0
作者：
SMAL, MA
COONEY, SJ
BALDO, BA
机构：
[1] ROYAL N SHORE HOSP,KOLLING INST MED RES,ST LEONARDS,NSW 2065,AUSTRALIA
[2] UNIV SYDNEY,DEPT MED,SYDNEY,NSW 2006,AUSTRALIA
来源：
JOURNAL OF LIPID MEDIATORS | 1991年 / 4卷 / 03期
关键词：
PLATELET AGGREGATION; PLATELET-ACTIVATING FACTOR; ANTI-PAF;
D O I：
暂无
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Platelet-activating factor (PAF) is the most potent platelet agonist known. PAF-induced platelet aggregation was blocked by pre-incubation of PAF with the immunoglobulin fraction from sheep or rabbit anti-PAF anti-serum. Inhibition was specific for PAF and was dependent upon immunoglobulin and PAF concentrations. Antibody-mediated inhibition of PAF-activity may be a valuable method for studying the biological effects of PAF in some systems.
引用
收藏
页码：333 / 341
页数：9
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