CYCLANDELATE IN DIABETIC NEUROPATHY - A DOUBLE-BLIND, PLACEBO-CONTROLLED, RANDOMIZED, CROSS-OVER STUDY

被引：0

作者：

HEIMANS, JJ ^{[1
]}

DRUKARCH, B ^{[1
]}

MATTHAEI, I ^{[1
]}

IJFF, GA ^{[1
]}

BERTELSMANN, FW ^{[1
]}

STRIJERS, RLM ^{[1
]}

NAUTA, J ^{[1
]}

机构：

[1] FREE UNIV AMSTERDAM HOSP,DEPT THEORY MED,1007 MB AMSTERDAM,NETHERLANDS

来源：

ACTA NEUROLOGICA SCANDINAVICA | 1991年 / 84卷 / 06期

关键词：

DIABETIC NEUROPATHY; THERAPY; CYCLANDELATE;

D O I：

暂无

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Cyclandelate has the ability to improve the rheological properties of the blood and therefore may improve blood supply of peripheral nerves. Previous studies in diabetic neuropathy have shown beneficial effects of the drug. We performed a double-blind, placebo-controlled, cross-over study in 40 diabetic patients with cyclandelate in a dose of 1600 mg daily. Motor and sensory nerve conduction velocities, late responses, thermal discrimination thresholds, vibration perception thresholds and pain scores were studied. We were not able to show any positive effect of the drug and therefore conclude that cyclandelate is not effective in the treatment of diabetic neuropathy.

引用

页码：483 / 486

页数：4

共 50 条

[1] Glyceryl trinitrate spray in the management of painful diabetic neuropathy: A randomized double blind placebo controlled cross-over study
Agrawal, R. P.
Choudhary, Ramdev
Sharma, Poornima
Sharma, Srikant
Beniwal, R.
Kaswan, K.
Kochar, D. K.
DIABETES RESEARCH AND CLINICAL PRACTICE, 2007, 77 (02) : 161 - 167
[2] GANGLIOSIDES IN THE TREATMENT OF DIABETIC NEUROPATHY - A RANDOMIZED, DOUBLE-BLIND, PLACEBO-CONTROLLED, DOSE-FINDING STUDY
LINGETTI, M
COTO, V
RENGO, F
SGAMBATO, S
INNOCENTI, A
FIORI, MG
DIABETES NUTRITION & METABOLISM, 1992, 5 (04) : 275 - 282
[3] CYCLANDELATE VERSUS PROPRANOLOL IN THE PROPHYLAXIS OF MIGRAINE - A DOUBLE-BLIND PLACEBO-CONTROLLED STUDY
GERBER, WD
SCHELLENBERG, G
THOM, M
HAUFE, C
BOLSCHE, F
WEDEKIND, W
NIEDERBERGER, U
SOYKA, D
FUNCTIONAL NEUROLOGY, 1995, 10 (01) : 27 - 35
[4] CLOMIPRAMINE VS DESIPRAMINE VS PLACEBO IN THE TREATMENT OF DIABETIC NEUROPATHY SYMPTOMS - A DOUBLE-BLIND CROSS-OVER STUDY
SINDRUP, SH
GRAM, LF
SKJOLD, T
GRODUM, E
BROSEN, K
BECKNIELSEN, H
BRITISH JOURNAL OF CLINICAL PHARMACOLOGY, 1990, 30 (05) : 683 - 691
[5] Management of diabetic neuropathy by sodium valproate and glyceryl trinitrate spray: A prospective double-blind randomized placebo-controlled study
Agrawal, R. P.
Goswami, Jitender
Jain, Shreyans
Kochar, D. K.
DIABETES RESEARCH AND CLINICAL PRACTICE, 2009, 83 (03) : 371 - 378
[6] Clinical efficacy and central mechanisms of cyclandelate in migraine: A double-blind placebo-controlled study
Siniatchkin, M
Gerber, WD
Vein, A
FUNCTIONAL NEUROLOGY, 1998, 13 (01) : 47 - 56
[7] Venlafaxine extended release in the treatment of painful diabetic neuropathy: a double-blind, placebo-controlled study
Rowbotham, MC
Goli, V
Kunz, NR
Lei, D
PAIN, 2004, 110 (03) : 697 - 706
[8] Lacosamide in painful diabetic peripheral neuropathy - A phase 2 double-blind placebo-controlled study
Rauck, Richard L.
Shaibani, Aziz
Biton, Victor
Simpson, Jqff
Koch, Brigitte
CLINICAL JOURNAL OF PAIN, 2007, 23 (02) : 150 - 158
[9] EFFECTS OF CYCLANDELATE ON THE CNS - A DOUBLE-BLIND, PLACEBO-CONTROLLED STUDY IN YOUNG, HEALTHY-SUBJECTS
DIMPFEL, W
NETTER, P
SPULER, M
WEDEKIND, W
KLINISCHE WOCHENSCHRIFT, 1991, 69 (07): : 313 - 319
[10] 0.075% capsaicin lotion for the treatment of painful diabetic neuropathy: A randomized, double-blind, crossover, placebo-controlled trial
Kulkantrakorn, Kongkiat
Chomjit, Assawin
Sithinamsuwan, Pasiri
Tharavanij, Thipaporn
Suwankanoknark, Juthamas
Napunnaphat, Phunyada
JOURNAL OF CLINICAL NEUROSCIENCE, 2019, 62 : 174 - 179

← 1 2 3 4 5 →