EFFECTS OF THE CALCIUM-ANTAGONIST NILVADIPINE ON FOCAL CEREBRAL-ISCHEMIA IN SPONTANEOUSLY HYPERTENSIVE RATS

被引：13

作者：

SHIINO, A ^{[1
]}

MATSUDA, M ^{[1
]}

SUSUMU, T ^{[1
]}

HANDA, J ^{[1
]}

机构：

[1] SHIGA UNIV MED SCI, DEPT NEUROSURG, OTSU, SHIGA 52021, JAPAN

来源：

SURGICAL NEUROLOGY | 1991年 / 35卷 / 02期

关键词：

CALCIUM ANTAGONIST; SPONTANEOUSLY HYPERTENSIVE RAT; NILVADIPINE; MIDDLE CEREBRAL ARTERY; FOCAL CEREBRAL ISCHEMIA; CEREBRAL INFARCTION;

D O I：

10.1016/0090-3019(91)90259-C

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

We studied the efficacy of preischemic and postischemic systemic treatment with a new calcium antagonist nilvadipine in a permanent focal cerebral ischemia model of spontaneously hypertensive rats. Rats that underwent microsurgical middle cerebral artery occlusion were blindly assigned to a single intraperitoneal injection of nilvadipine (0.32 mg/kg) or the same amount of polyethylene glycol either 15 minutes before, immediately after, 1 hour after, or 3 hours after occlusion of the left middle cerebral artery. Neurological conditions of rats were closely examined, and rats were killed 24 hours later. Removed brains were sliced coronally, stained with triphenyltetrazolium choloride, and the size of infarct was determined. Although no neurologic improvements were observed in the treated rats, the area of infarcts was significantly reduced in the groups treated before, immediately after, and 1 hour after occlusion of the middle cerebral artery. Treatment started 3 hours after occlusion was ineffective.

引用

页码：105 / 110

页数：6

共 36 条

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