TESTS OF OPIOID DEFICIENCY HYPOTHESES OF ALCOHOLISM

被引:74
作者
REID, LD
DELCONTE, JD
NICHOLS, ML
BILSKY, EJ
HUBBELL, CL
机构
[1] Department of Psychology, Rensselaer Polytechnic Institute, Troy
关键词
OPIOIDS; MORPHINE; NALOXONE; ALCOHOL ABUSE; ALCOHOLISM;
D O I
10.1016/0741-8329(91)90305-G
中图分类号
R194 [卫生标准、卫生检查、医药管理];
学科分类号
摘要
Eighty-three male rats were maintained on a daily regimen involving 22 h of deprivation of fluids followed by 2 h of access to water and a sweetened alcoholic beverage (12% ethanol, 5% sucrose). After about 3 weeks of such a regimen, rats eventually take considerable amounts of ethanol daily. In the present study, a series of injections of opioids was given subsequent to establishing stable daily intakes of ethanol. Specifically, before a day's opportunity to take fluids, some rats were given a small dose of morphine (2.0 mg/kg), while others were given a dose of naloxone (4.0 mg/kg). When morphine was given 0.5 h before the opportunity to drink, intake of ethanol was increased. However, when morphine was given 4.0 h before the opportunity, intake of ethanol was decreased. Nearly opposite effects were observed when naloxone was given. Other experiments tested the effects of giving morphine 4.0 h before the opportunity to drink plus the effects of a small dose of naloxone or plus the effects of a small dose of morphine. Morphine given 4.0 h before potentiated the effects of a small dose of naloxone and attenuated the effects of another dose of morphine. The effects of morphine were also shown to be similar among rats taking a solution of ethanol and water rather than a sweetened solution. These data provide support for the idea that surfeits, not deficits, in opioidergic activity increase propensity to take alcoholic beverages.
引用
收藏
页码:247 / 257
页数:11
相关论文
共 56 条
[1]  
AKKOK F, 1988, B PSYCHONOMIC SOC, V26, P556
[2]  
ARSLAN Y, 1986, PHYSL THIRST SODIUM, P527
[3]  
Beaman C M, 1984, Alcohol, V1, P39
[4]  
BLOOM FE, 1982, BETA CARBOLINES TETR, P401
[5]   ENKEPHALINASE INHIBITION AND PRECURSOR AMINO-ACID LOADING IMPROVES INPATIENT TREATMENT OF ALCOHOL AND POLYDRUG ABUSERS - DOUBLE-BLIND PLACEBO-CONTROLLED STUDY OF THE NUTRITIONAL ADJUNCT SAAVE [J].
BLUM, K ;
TRACHTENBERG, MC ;
ELLIOTT, CE ;
DINGLER, ML ;
SEXTON, RL ;
SAMUELS, AI ;
CATALDIE, L .
ALCOHOL, 1988, 5 (06) :481-493
[6]   ENKEPHALINASE INHIBITION - REGULATION OF ETHANOL INTAKE IN GENETICALLY PREDISPOSED MICE [J].
BLUM, K ;
BRIGGS, AH ;
TRACHTENBERG, MC ;
DELALLO, L ;
WALLACE, JE .
ALCOHOL, 1987, 4 (06) :449-456
[7]  
BLUM K, 1980, ALCOHOL TOLERANCE DE, P371
[8]  
Bozarth M. A., 1987, METHODS ASSESSING RE
[9]   LACK OF EFFECT OF DOPAMINE RECEPTOR BLOCKADE ON VOLUNTARY ETHANOL-CONSUMPTION IN RATS [J].
BROWN, ZW ;
GILL, K ;
ABITBOL, M ;
AMIT, Z .
BEHAVIORAL AND NEURAL BIOLOGY, 1982, 36 (03) :291-294
[10]   CHRONICALLY ADMINISTERED MORPHINE, CIRCADIAN CYCLICITY, AND INTAKE OF AN ALCOHOLIC BEVERAGE [J].
CHOI, HW ;
WILD, KD ;
HUBBELL, CL ;
REID, LD .
ALCOHOL, 1990, 7 (01) :7-10