ALTERNATIVE SPLICING OF THE BETA-A4 AMYLOID GENE OF ALZHEIMERS-DISEASE IN CORTEX OF CONTROL AND ALZHEIMERS-DISEASE PATIENTS

被引：64
|
作者：
KONIG, G
SALBAUM, JM
WIESTLER, O
LANG, W
SCHMITT, HP
MASTERS, CL
BEYREUTHER, K
机构：
[1] UNIV HOSP ZURICH,INST PATHOL,CH-8091 ZURICH,SWITZERLAND
[2] UNIV HEIDELBERG,INST NEUROPATHOL,W-6900 HEIDELBERG,GERMANY
[3] UNIV MELBOURNE,DEPT PATHOL,PARKVILLE,VIC 3052,AUSTRALIA
来源：
MOLECULAR BRAIN RESEARCH | 1991年 / 9卷 / 03期
关键词：
APP GENE; AMYLOID PRECURSOR GENE; ALTERNATIVE SPLICING; ALZHEIMERS DISEASE; BETA-A4; AMYLOID;
D O I：
10.1016/0169-328X(91)90010-U
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
An S1 nuclease protection assay was designed to study the splicing pattern of the alternatively spliced beta-A4 amyloid gene (APP gene) of Alzheimer's disease (AD). We determined the splicing pattern of the APP gene in fetal, adult, aged adult and AD human cortex. The results suggest that alternative splicing of the APP gene in AD is not significantly different from age-matched controls, but distinct from the developing fetal brain.
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页码：259 / 262
页数：4
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