GENETIC-VARIATION AMONG PNEUMOCYSTIS-CARINII HOMINIS ISOLATES IN RECURRENT PNEUMOCYSTOSIS

被引：157

作者：

KEELY, SP

STRINGER, JR

BAUGHMAN, RP

LINKE, MJ

WALZER, PD

SMULIAN, AG

机构：

[1] VET ADM MED CTR,CINCINNATI,OH 45220

[2] UNIV CINCINNATI,COLL MED,DEPT MOLEC GENET,CINCINNATI,OH

[3] UNIV CINCINNATI,COLL MED,DEPT BIOCHEM,CINCINNATI,OH

[4] UNIV CINCINNATI,COLL MED,DEPT MICROBIOL,CINCINNATI,OH

[5] UNIV CINCINNATI,COLL MED,DEPT INTERNAL MED,DIV INFECT DIS,CINCINNATI,OH 45267

来源：

JOURNAL OF INFECTIOUS DISEASES | 1995年 / 172卷 / 02期

关键词：

D O I：

10.1093/infdis/172.2.595

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Pneumocystis carinii hominis is a ubiquitous organism that causes pneumonia in immunocompromised persons. Paired P. carinii hominis isolates from human immunodeficiency virus-infected persons who had two episodes of pneumocystosis were examined for genetic heterogeneity. Genetic variation was detected by sequence comparison of a portion of the mitochondrial ribosomal RNA gene, In 5 of 10 patients experiencing two episodes of pneumocystosis, genetically distinct isolates were associated with each episode. These included 4 of 6 patients whose second episode of pneumocystosis occurred >6 months after their initial bout. The genetic data support the hypothesis that some recurrent episodes of P. carinii hominis pneumonia are caused by reinfection rather than by reactivation of latent infection.

引用

页码：595 / 598

页数：4

共 15 条

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